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Defect of Adaptation to Hypoxia in Patients With COPD Due to Reduction of Histone Deacetylase 7

BACKGROUND: Hypoxia inducible factor (HIF)-1 plays an important role in cellular adaptation to hypoxia by activating oxygen-regulated genes such as vascular endothelial growth factor (VEGF) and erythropoietin. Sputum VEGF levels are reported to be decreased in COPD, despite hypoxia. Here we show tha...

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Detalles Bibliográficos
Autores principales:	To, Masako, Yamamura, Satoshi, Akashi, Kenichi, Charron, Catherine E., Barnes, Peter J., Ito, Kazuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American College of Chest Physicians 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342783/ https://www.ncbi.nlm.nih.gov/pubmed/22172637 http://dx.doi.org/10.1378/chest.11-1536

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