CTCF Binding Elements Mediate Control of V(D)J Recombination

Immunoglobulin heavy chain (IgH) variable region exons are assembled from V(H), D and J(H) gene segments in developing B lymphocytes. Within the 2.7 megabase (Mb) mouse IgH locus (IgH), V(D)J recombination is regulated to ensure specific and diverse antibody repertoires. Herein, we report a key IgH...

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Detalles Bibliográficos
Autores principales: Guo, Chunguang, Yoon, Hye Suk, Franklin, Andrew, Jain, Suvi, Ebert, Anja, Cheng, Hwei-Ling, Hansen, Erica, Despo, Orion, Bossen, Claudia, Vettermann, Christian, Bates, Jamie G., Richards, Nicholas, Myers, Darienne, Patel, Harin, Gallagher, Michael, Schlissel, Mark S., Murre, Cornelis, Busslinger, Meinrad, Giallourakis, Cosmas C., Alt, Frederick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342812/
https://www.ncbi.nlm.nih.gov/pubmed/21909113
http://dx.doi.org/10.1038/nature10495

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