Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

BACKGROUND: The presence of somatic mitochondrial DNA (mtDNA) mutations in cancer cells has been interpreted in controversial ways, ranging from random neutral accumulation of mutations, to positive selection for high pathogenicity, or conversely to purifying selection against high pathogenicity var...

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Detalles Bibliográficos
Autores principales: Pereira, Luísa, Soares, Pedro, Máximo, Valdemar, Samuels, David C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342922/
https://www.ncbi.nlm.nih.gov/pubmed/22299657
http://dx.doi.org/10.1186/1471-2407-12-53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342922/
https://www.ncbi.nlm.nih.gov/pubmed/22299657
http://dx.doi.org/10.1186/1471-2407-12-53

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