The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex

The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and...

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Autores principales: Fernandes, Jason, Jayaraman, Bhargavi, Frankel, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
RNA Families
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342944/
https://www.ncbi.nlm.nih.gov/pubmed/22258145
http://dx.doi.org/10.4161/rna.9.1.18178
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author Fernandes, Jason
Jayaraman, Bhargavi
Frankel, Alan
author_facet Fernandes, Jason
Jayaraman, Bhargavi
Frankel, Alan
author_sort Fernandes, Jason
collection PubMed
description The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and unspliced viral mRNA transcripts, and serves as an RNA framework onto which multiple molecules of the viral protein Rev assemble. The Rev-RRE oligomeric complex mediates the export of these messages from the nucleus to the cytoplasm, where they are translated to produce essential viral proteins and/or packaged as genomes for new virions.
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spelling pubmed-33429442012-05-04 The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex Fernandes, Jason Jayaraman, Bhargavi Frankel, Alan RNA Biol RNA Families The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and unspliced viral mRNA transcripts, and serves as an RNA framework onto which multiple molecules of the viral protein Rev assemble. The Rev-RRE oligomeric complex mediates the export of these messages from the nucleus to the cytoplasm, where they are translated to produce essential viral proteins and/or packaged as genomes for new virions. Landes Bioscience 2012-01-01 /pmc/articles/PMC3342944/ /pubmed/22258145 http://dx.doi.org/10.4161/rna.9.1.18178 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle RNA Families
Fernandes, Jason
Jayaraman, Bhargavi
Frankel, Alan
The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex
title The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex
title_full The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex
title_fullStr The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex
title_full_unstemmed The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex
title_short The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex
title_sort hiv-1 rev response element: an rna scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex
topic RNA Families
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342944/
https://www.ncbi.nlm.nih.gov/pubmed/22258145
http://dx.doi.org/10.4161/rna.9.1.18178
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