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Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation

BACKGROUND: Aortic aneurysm is a common but life-threatening disease among the elderly, for which no effective medical therapy is currently available. Activation of prostaglandin E(2) (PGE(2)) is known to increase the expression of matrix metalloproteinase (MMP) and the release of inflammatory cytok...

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Detalles Bibliográficos
Autores principales:	Yokoyama, Utako, Ishiwata, Ryo, Jin, Mei-Hua, Kato, Yuko, Suzuki, Orie, Jin, Huiling, Ichikawa, Yasuhiro, Kumagaya, Syun, Katayama, Yuzo, Fujita, Takayuki, Okumura, Satoshi, Sato, Motohiko, Sugimoto, Yukihiko, Aoki, Hiroki, Suzuki, Shinichi, Masuda, Munetaka, Minamisawa, Susumu, Ishikawa, Yoshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343028/ https://www.ncbi.nlm.nih.gov/pubmed/22570740 http://dx.doi.org/10.1371/journal.pone.0036724

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