The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination

Class-switch recombination (CSR), induced by activation-induced cytidine deaminase (AID), can be divided into two phases: DNA cleavage of the switch (S) regions and the joining of the cleaved ends of the different S regions. Here, we show that the DSIF complex (Spt4 and Spt5), a transcription elonga...

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Detalles Bibliográficos
Autores principales: Stanlie, Andre, Begum, Nasim A., Akiyama, Hideo, Honjo, Tasuku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343088/
https://www.ncbi.nlm.nih.gov/pubmed/22570620
http://dx.doi.org/10.1371/journal.pgen.1002675

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