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InsP3 Receptor Regulates Hepatic Gluconeogenesis in Fasting and Diabetes

In the fasted state, increases in circulating glucagon promote hepatic glucose production through induction of the gluconeogenic program. Triggering of the cAMP pathway increases gluconeogenic gene expression via the de-phosphorylation of the CREB coactivator CRTC2 (1). Glucagon promotes CRTC2 depho...

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Detalles Bibliográficos
Autores principales:	Wang, Yiguo, Li, Gang, Goode, Jason, Paz, Jose C., Ouyang, Kunfu, Screaton, Robert, Fischer, Wolfgang H., Chen, Ju, Tabas, Ira, Montminy, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343222/ https://www.ncbi.nlm.nih.gov/pubmed/22495310 http://dx.doi.org/10.1038/nature10988

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