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Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities
To endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343264/ https://www.ncbi.nlm.nih.gov/pubmed/22566975 http://dx.doi.org/10.3389/fimmu.2012.00103 |
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author | Madorsky-Rowdo, Florencia Paula Lacreu, María Laura Mordoh, José |
author_facet | Madorsky-Rowdo, Florencia Paula Lacreu, María Laura Mordoh, José |
author_sort | Madorsky-Rowdo, Florencia Paula |
collection | PubMed |
description | To endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed to this disease. New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses triggered by adjuvants, as well as the understanding of the role of immunosuppressor molecules such as cytotoxic T-lymphocyte antigen-4 (CTLA-4), which led to the recent approval of the anti-CTLA-4 monoclonal antibody ipilimumab, have opened new hopes about the installment of immunotherapy as a new modality to treat cancer. |
format | Online Article Text |
id | pubmed-3343264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33432642012-05-07 Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities Madorsky-Rowdo, Florencia Paula Lacreu, María Laura Mordoh, José Front Immunol Immunology To endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed to this disease. New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses triggered by adjuvants, as well as the understanding of the role of immunosuppressor molecules such as cytotoxic T-lymphocyte antigen-4 (CTLA-4), which led to the recent approval of the anti-CTLA-4 monoclonal antibody ipilimumab, have opened new hopes about the installment of immunotherapy as a new modality to treat cancer. Frontiers Research Foundation 2012-05-04 /pmc/articles/PMC3343264/ /pubmed/22566975 http://dx.doi.org/10.3389/fimmu.2012.00103 Text en Copyright © 2012 Madorsky-Rowdo, Lacreu and Mordoh. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Immunology Madorsky-Rowdo, Florencia Paula Lacreu, María Laura Mordoh, José Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities |
title | Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities |
title_full | Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities |
title_fullStr | Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities |
title_full_unstemmed | Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities |
title_short | Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities |
title_sort | melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343264/ https://www.ncbi.nlm.nih.gov/pubmed/22566975 http://dx.doi.org/10.3389/fimmu.2012.00103 |
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