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Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities

To endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed...

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Autores principales: Madorsky-Rowdo, Florencia Paula, Lacreu, María Laura, Mordoh, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343264/
https://www.ncbi.nlm.nih.gov/pubmed/22566975
http://dx.doi.org/10.3389/fimmu.2012.00103
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author Madorsky-Rowdo, Florencia Paula
Lacreu, María Laura
Mordoh, José
author_facet Madorsky-Rowdo, Florencia Paula
Lacreu, María Laura
Mordoh, José
author_sort Madorsky-Rowdo, Florencia Paula
collection PubMed
description To endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed to this disease. New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses triggered by adjuvants, as well as the understanding of the role of immunosuppressor molecules such as cytotoxic T-lymphocyte antigen-4 (CTLA-4), which led to the recent approval of the anti-CTLA-4 monoclonal antibody ipilimumab, have opened new hopes about the installment of immunotherapy as a new modality to treat cancer.
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spelling pubmed-33432642012-05-07 Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities Madorsky-Rowdo, Florencia Paula Lacreu, María Laura Mordoh, José Front Immunol Immunology To endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed to this disease. New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses triggered by adjuvants, as well as the understanding of the role of immunosuppressor molecules such as cytotoxic T-lymphocyte antigen-4 (CTLA-4), which led to the recent approval of the anti-CTLA-4 monoclonal antibody ipilimumab, have opened new hopes about the installment of immunotherapy as a new modality to treat cancer. Frontiers Research Foundation 2012-05-04 /pmc/articles/PMC3343264/ /pubmed/22566975 http://dx.doi.org/10.3389/fimmu.2012.00103 Text en Copyright © 2012 Madorsky-Rowdo, Lacreu and Mordoh. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Immunology
Madorsky-Rowdo, Florencia Paula
Lacreu, María Laura
Mordoh, José
Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities
title Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities
title_full Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities
title_fullStr Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities
title_full_unstemmed Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities
title_short Melanoma Vaccines and Modulation of the Immune System in the Clinical Setting: Building from New Realities
title_sort melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343264/
https://www.ncbi.nlm.nih.gov/pubmed/22566975
http://dx.doi.org/10.3389/fimmu.2012.00103
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