Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum

The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bi...

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Detalles Bibliográficos
Autores principales: Nollmann, Friederike I, Dowling, Andrea, Kaiser, Marcel, Deckmann, Klaus, Grösch, Sabine, ffrench-Constant, Richard, Bode, Helge B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343279/
https://www.ncbi.nlm.nih.gov/pubmed/22563351
http://dx.doi.org/10.3762/bjoc.8.60
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author Nollmann, Friederike I
Dowling, Andrea
Kaiser, Marcel
Deckmann, Klaus
Grösch, Sabine
ffrench-Constant, Richard
Bode, Helge B
author_facet Nollmann, Friederike I
Dowling, Andrea
Kaiser, Marcel
Deckmann, Klaus
Grösch, Sabine
ffrench-Constant, Richard
Bode, Helge B
author_sort Nollmann, Friederike I
collection PubMed
description The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria.
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spelling pubmed-33432792012-05-04 Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum Nollmann, Friederike I Dowling, Andrea Kaiser, Marcel Deckmann, Klaus Grösch, Sabine ffrench-Constant, Richard Bode, Helge B Beilstein J Org Chem Letter The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria. Beilstein-Institut 2012-04-11 /pmc/articles/PMC3343279/ /pubmed/22563351 http://dx.doi.org/10.3762/bjoc.8.60 Text en Copyright © 2012, Nollmann et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Nollmann, Friederike I
Dowling, Andrea
Kaiser, Marcel
Deckmann, Klaus
Grösch, Sabine
ffrench-Constant, Richard
Bode, Helge B
Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
title Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
title_full Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
title_fullStr Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
title_full_unstemmed Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
title_short Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
title_sort synthesis of szentiamide, a depsipeptide from entomopathogenic xenorhabdus szentirmaii with activity against plasmodium falciparum
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343279/
https://www.ncbi.nlm.nih.gov/pubmed/22563351
http://dx.doi.org/10.3762/bjoc.8.60
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