Cargando…
Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages
Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of the process of internalization of silver nanoparticles by macrophages. When macrophages were pre-t...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343436/ https://www.ncbi.nlm.nih.gov/pubmed/22477013 http://dx.doi.org/10.3349/ymj.2012.53.3.654 |
_version_ | 1782231823954214912 |
---|---|
author | Kim, Seungjae Choi, In-Hong |
author_facet | Kim, Seungjae Choi, In-Hong |
author_sort | Kim, Seungjae |
collection | PubMed |
description | Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of the process of internalization of silver nanoparticles by macrophages. When macrophages were pre-treated with inhibitors to phagocytosis, caveolin-mediated endocytosis, or clathrin-mediated endocytosis, prior to exposure to silver nanoparticles, Interleukin-8 (IL-8) production was inhibited. Although cell death was not reduced, the inflammatory response by macrophages was compromised by phagocytosis and endocytosis inhibitors. |
format | Online Article Text |
id | pubmed-3343436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-33434362012-05-21 Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages Kim, Seungjae Choi, In-Hong Yonsei Med J Brief Communication Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of the process of internalization of silver nanoparticles by macrophages. When macrophages were pre-treated with inhibitors to phagocytosis, caveolin-mediated endocytosis, or clathrin-mediated endocytosis, prior to exposure to silver nanoparticles, Interleukin-8 (IL-8) production was inhibited. Although cell death was not reduced, the inflammatory response by macrophages was compromised by phagocytosis and endocytosis inhibitors. Yonsei University College of Medicine 2012-05-01 2012-03-28 /pmc/articles/PMC3343436/ /pubmed/22477013 http://dx.doi.org/10.3349/ymj.2012.53.3.654 Text en © Copyright: Yonsei University College of Medicine 2012 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Kim, Seungjae Choi, In-Hong Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages |
title | Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages |
title_full | Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages |
title_fullStr | Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages |
title_full_unstemmed | Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages |
title_short | Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages |
title_sort | phagocytosis and endocytosis of silver nanoparticles induce interleukin-8 production in human macrophages |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343436/ https://www.ncbi.nlm.nih.gov/pubmed/22477013 http://dx.doi.org/10.3349/ymj.2012.53.3.654 |
work_keys_str_mv | AT kimseungjae phagocytosisandendocytosisofsilvernanoparticlesinduceinterleukin8productioninhumanmacrophages AT choiinhong phagocytosisandendocytosisofsilvernanoparticlesinduceinterleukin8productioninhumanmacrophages |