Rorα is essential for nuocyte development

Nuocytes are essential in innate type-2 immunity and contribute to the exacerbation of asthma responses. Here we show that nuocytes arise in the bone marrow and differentiate from common lymphoid progenitors, which makes them distinct new members of the lymphoid lineage. Nuocytes required interleuki...

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Detalles Bibliográficos
Autores principales: Wong, See Heng, Walker, Jennifer A., Jolin, Helen E., Drynan, Lesley F., Hams, Emily, Camelo, Ana, Barlow, Jillian L., Neill, Daniel R., Panova, Veera, Koch, Ute, Radtke, Freddy, Hardman, Clare S., Hwang, You Yi, Fallon, Padraic G., McKenzie, Andrew N.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343633/
https://www.ncbi.nlm.nih.gov/pubmed/22267218
http://dx.doi.org/10.1038/ni.2208
Descripción
Sumario:Nuocytes are essential in innate type-2 immunity and contribute to the exacerbation of asthma responses. Here we show that nuocytes arise in the bone marrow and differentiate from common lymphoid progenitors, which makes them distinct new members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signalling for development in vitro. Double negative 1 (DN1) and DN2 pro-T-cell progenitors maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor Rorα was critical for nuocyte development and their role in parasitic worm expulsion.

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