Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates

[Image: see text] A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 20 min microwave protocol using Pd(O(2)CCF(3)), 6-methyl-2,2′-bipyridyl, TFA, and M...

Descripción completa

Detalles Bibliográficos
Autores principales: Sävmarker, Jonas, Rydfjord, Jonas, Gising, Johan, Odell, Luke R., Larhed, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343701/
https://www.ncbi.nlm.nih.gov/pubmed/22509992
http://dx.doi.org/10.1021/ol300813c
_version_ 1782231837296295936
author Sävmarker, Jonas
Rydfjord, Jonas
Gising, Johan
Odell, Luke R.
Larhed, Mats
author_facet Sävmarker, Jonas
Rydfjord, Jonas
Gising, Johan
Odell, Luke R.
Larhed, Mats
author_sort Sävmarker, Jonas
collection PubMed
description [Image: see text] A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 20 min microwave protocol using Pd(O(2)CCF(3)), 6-methyl-2,2′-bipyridyl, TFA, and MeOH, providing the corresponding arylamidines in moderate to excellent yields.
format Online
Article
Text
id pubmed-3343701
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-33437012012-05-04 Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates Sävmarker, Jonas Rydfjord, Jonas Gising, Johan Odell, Luke R. Larhed, Mats Org Lett [Image: see text] A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 20 min microwave protocol using Pd(O(2)CCF(3)), 6-methyl-2,2′-bipyridyl, TFA, and MeOH, providing the corresponding arylamidines in moderate to excellent yields. American Chemical Society 2012-04-17 2012-05-04 /pmc/articles/PMC3343701/ /pubmed/22509992 http://dx.doi.org/10.1021/ol300813c Text en Copyright © 2012 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Sävmarker, Jonas
Rydfjord, Jonas
Gising, Johan
Odell, Luke R.
Larhed, Mats
Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
title Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
title_full Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
title_fullStr Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
title_full_unstemmed Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
title_short Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
title_sort direct palladium(ii)-catalyzed synthesis of arylamidines from aryltrifluoroborates
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343701/
https://www.ncbi.nlm.nih.gov/pubmed/22509992
http://dx.doi.org/10.1021/ol300813c
work_keys_str_mv AT savmarkerjonas directpalladiumiicatalyzedsynthesisofarylamidinesfromaryltrifluoroborates
AT rydfjordjonas directpalladiumiicatalyzedsynthesisofarylamidinesfromaryltrifluoroborates
AT gisingjohan directpalladiumiicatalyzedsynthesisofarylamidinesfromaryltrifluoroborates
AT odellluker directpalladiumiicatalyzedsynthesisofarylamidinesfromaryltrifluoroborates
AT larhedmats directpalladiumiicatalyzedsynthesisofarylamidinesfromaryltrifluoroborates

Ejemplares similares