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Plaque Vulnerability in Internal Carotid Arteries with Positive Remodeling
BACKGROUND: This study aimed to evaluate the efficacy of assessing positive remodeling for predicting future stroke events in the internal carotid artery. We therefore assessed narrowing of the carotid artery lumen using multidetector-row computer tomography (MDCT) angiography and carotid plaque cha...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343763/ https://www.ncbi.nlm.nih.gov/pubmed/22566983 http://dx.doi.org/10.1159/000328645 |
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author | Miura, Toshiyasu Matsukawa, Noriyuki Sakurai, Keita Katano, Hiroyuki Ueki, Yoshino Okita, Kenji Yamada, Kazuo Ojika, Kosei |
author_facet | Miura, Toshiyasu Matsukawa, Noriyuki Sakurai, Keita Katano, Hiroyuki Ueki, Yoshino Okita, Kenji Yamada, Kazuo Ojika, Kosei |
author_sort | Miura, Toshiyasu |
collection | PubMed |
description | BACKGROUND: This study aimed to evaluate the efficacy of assessing positive remodeling for predicting future stroke events in the internal carotid artery. We therefore assessed narrowing of the carotid artery lumen using multidetector-row computer tomography (MDCT) angiography and carotid plaque characteristics using black-blood (BB) magnetic resonance (MR). METHODS: We retrospectively selected 17 symptomatic and 11 asymptomatic lesions with luminal narrowing >50%. We compared remodeling parameters of luminal stenosis (remodeling ratio, RR/remodeling index, RI) using MDCT and MR intensities of atherosclerotic plaque contents using the BB technique (relative signal intensity, rSI). We also confirmed the validity of the relationship between MR intensity and atherosclerotic plaque contents by histology. The levels of biological markers related to vessel atherosclerosis were measured. RESULTS: Plaque lesions with positive remodeling in carotid arteries were associated with a significantly higher prevalence of stroke compared with plaques with negative remodeling (p < 0.05). Radiologic and histologic analyses determined that plaques with positive remodeling had higher signal intensities (with respect to their lipid-rich content or to hemorrhage) compared with negative remodeling (correlation coefficients: RI and rSI, r = 0.41, p < 0.05; RR and rSI, r = 0.50, p < 0.05). Levels of biological markers, including high-sensitivity C-reactive protein, hemoglobin A1C, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, were not useful for predicting stroke events. CONCLUSIONS: The results of this study suggest that the combined analysis of RR, RI and rSI could potentially help to predict future stroke events. |
format | Online Article Text |
id | pubmed-3343763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-33437632012-05-07 Plaque Vulnerability in Internal Carotid Arteries with Positive Remodeling Miura, Toshiyasu Matsukawa, Noriyuki Sakurai, Keita Katano, Hiroyuki Ueki, Yoshino Okita, Kenji Yamada, Kazuo Ojika, Kosei Cerebrovasc Dis Extra Original Paper BACKGROUND: This study aimed to evaluate the efficacy of assessing positive remodeling for predicting future stroke events in the internal carotid artery. We therefore assessed narrowing of the carotid artery lumen using multidetector-row computer tomography (MDCT) angiography and carotid plaque characteristics using black-blood (BB) magnetic resonance (MR). METHODS: We retrospectively selected 17 symptomatic and 11 asymptomatic lesions with luminal narrowing >50%. We compared remodeling parameters of luminal stenosis (remodeling ratio, RR/remodeling index, RI) using MDCT and MR intensities of atherosclerotic plaque contents using the BB technique (relative signal intensity, rSI). We also confirmed the validity of the relationship between MR intensity and atherosclerotic plaque contents by histology. The levels of biological markers related to vessel atherosclerosis were measured. RESULTS: Plaque lesions with positive remodeling in carotid arteries were associated with a significantly higher prevalence of stroke compared with plaques with negative remodeling (p < 0.05). Radiologic and histologic analyses determined that plaques with positive remodeling had higher signal intensities (with respect to their lipid-rich content or to hemorrhage) compared with negative remodeling (correlation coefficients: RI and rSI, r = 0.41, p < 0.05; RR and rSI, r = 0.50, p < 0.05). Levels of biological markers, including high-sensitivity C-reactive protein, hemoglobin A1C, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, were not useful for predicting stroke events. CONCLUSIONS: The results of this study suggest that the combined analysis of RR, RI and rSI could potentially help to predict future stroke events. S. Karger AG 2011-05-31 /pmc/articles/PMC3343763/ /pubmed/22566983 http://dx.doi.org/10.1159/000328645 Text en Copyright © 2011 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Original Paper Miura, Toshiyasu Matsukawa, Noriyuki Sakurai, Keita Katano, Hiroyuki Ueki, Yoshino Okita, Kenji Yamada, Kazuo Ojika, Kosei Plaque Vulnerability in Internal Carotid Arteries with Positive Remodeling |
title | Plaque Vulnerability in Internal Carotid Arteries with Positive Remodeling |
title_full | Plaque Vulnerability in Internal Carotid Arteries with Positive Remodeling |
title_fullStr | Plaque Vulnerability in Internal Carotid Arteries with Positive Remodeling |
title_full_unstemmed | Plaque Vulnerability in Internal Carotid Arteries with Positive Remodeling |
title_short | Plaque Vulnerability in Internal Carotid Arteries with Positive Remodeling |
title_sort | plaque vulnerability in internal carotid arteries with positive remodeling |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343763/ https://www.ncbi.nlm.nih.gov/pubmed/22566983 http://dx.doi.org/10.1159/000328645 |
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