Fluphenazine dihydro­chloride dimethanol solvate

In the title compound {systematic name: 1-(2-hy­droxy­eth­yl)-4-[3-(2-trifluoro­methyl-10H-phenothia­zin-10-yl)prop­yl]piperazine-1,4-diium dichloride dimethanol disolvate}, C(22)H(28)F(3)N(3)OS(2+)·2Cl(−)·2CH(3)OH, the dihedral angle between the planes of the two outer benzene rings of the tricycli...

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Autores principales: Petrus, Joanna, Petrus, Rafał, Czarnik-Matusewicz, Bogusława
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343971/
https://www.ncbi.nlm.nih.gov/pubmed/22589880
http://dx.doi.org/10.1107/S1600536812008707
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author Petrus, Joanna
Petrus, Rafał
Czarnik-Matusewicz, Bogusława
author_facet Petrus, Joanna
Petrus, Rafał
Czarnik-Matusewicz, Bogusława
author_sort Petrus, Joanna
collection PubMed
description In the title compound {systematic name: 1-(2-hy­droxy­eth­yl)-4-[3-(2-trifluoro­methyl-10H-phenothia­zin-10-yl)prop­yl]piperazine-1,4-diium dichloride dimethanol disolvate}, C(22)H(28)F(3)N(3)OS(2+)·2Cl(−)·2CH(3)OH, the dihedral angle between the planes of the two outer benzene rings of the tricyclic phenothia­zine system is 46.91 (13)°. The piperazine ring adopts a chair conformation. The crystal structure is stabilized by O—H⋯Cl, N—H⋯Cl, C—H⋯O, C—H⋯Cl and C—H⋯F hydrogen bonds and contacts.
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spelling pubmed-33439712012-05-15 Fluphenazine dihydro­chloride dimethanol solvate Petrus, Joanna Petrus, Rafał Czarnik-Matusewicz, Bogusława Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound {systematic name: 1-(2-hy­droxy­eth­yl)-4-[3-(2-trifluoro­methyl-10H-phenothia­zin-10-yl)prop­yl]piperazine-1,4-diium dichloride dimethanol disolvate}, C(22)H(28)F(3)N(3)OS(2+)·2Cl(−)·2CH(3)OH, the dihedral angle between the planes of the two outer benzene rings of the tricyclic phenothia­zine system is 46.91 (13)°. The piperazine ring adopts a chair conformation. The crystal structure is stabilized by O—H⋯Cl, N—H⋯Cl, C—H⋯O, C—H⋯Cl and C—H⋯F hydrogen bonds and contacts. International Union of Crystallography 2012-03-10 /pmc/articles/PMC3343971/ /pubmed/22589880 http://dx.doi.org/10.1107/S1600536812008707 Text en © Petrus et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Petrus, Joanna
Petrus, Rafał
Czarnik-Matusewicz, Bogusława
Fluphenazine dihydro­chloride dimethanol solvate
title Fluphenazine dihydro­chloride dimethanol solvate
title_full Fluphenazine dihydro­chloride dimethanol solvate
title_fullStr Fluphenazine dihydro­chloride dimethanol solvate
title_full_unstemmed Fluphenazine dihydro­chloride dimethanol solvate
title_short Fluphenazine dihydro­chloride dimethanol solvate
title_sort fluphenazine dihydro­chloride dimethanol solvate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343971/
https://www.ncbi.nlm.nih.gov/pubmed/22589880
http://dx.doi.org/10.1107/S1600536812008707
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AT petrusrafał fluphenazinedihydrochloridedimethanolsolvate
AT czarnikmatusewiczbogusława fluphenazinedihydrochloridedimethanolsolvate

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