41-Azido-41-de­oxy­rapamycin

The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti­biotic mol­ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy­droxy groups giving an intra­molecular hydrogen bond to a ket...

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Detalles Bibliográficos
Autores principales: Xie, Lijun, Huang, Jie, Zuo, Jian, Yu, Hui, Cheng, Yuanrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344143/
https://www.ncbi.nlm.nih.gov/pubmed/22606146
http://dx.doi.org/10.1107/S1600536812012548
Descripción
Sumario:The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti­biotic mol­ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy­droxy groups giving an intra­molecular hydrogen bond to a ketone O-atom acceptor. The mol­ecules also form inter­molecular hy­droxy–ketone O—H⋯O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å(3) solvent-accessible voids.

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