6-Methyl­ideneandrost-4-ene-3,17-dione

In the title compound, C(20)H(26)O(2), which is the 6-methyl­ene derivative of androstenedione and a synthetic percursor of exemestane, the steroid A ring approximates to a sofa (or envelope) conformation, with the methyl­ene group adjacent to the link to the B ring lying out of the plane of the oth...

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Detalles Bibliográficos
Autores principales: Andrade, L. C. R., de Almeida, M. J. M., Fernandes Roleira, F. M., Varela, C. L., Tavares da Silva, E. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344189/
https://www.ncbi.nlm.nih.gov/pubmed/22606192
http://dx.doi.org/10.1107/S1600536812013207
Descripción
Sumario:In the title compound, C(20)H(26)O(2), which is the 6-methyl­ene derivative of androstenedione and a synthetic percursor of exemestane, the steroid A ring approximates to a sofa (or envelope) conformation, with the methyl­ene group adjacent to the link to the B ring lying out of the plane of the other atoms. The B and C rings have slightly flattened chair conformations and the D ring is an envelope, with the CH group forming the flap. In the crystal, mol­ecules are linked by two distinct C—H⋯O hydrogen bonds, involving acidic H atoms close to C=C and C=O double bonds.

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