Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield.

Detalles Bibliográficos
Autores principales: Du, Zhenting, Si, Changmei, Li, Youqiang, Wang, Yin, Lu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344240/
https://www.ncbi.nlm.nih.gov/pubmed/22606004
http://dx.doi.org/10.3390/ijms13044696
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author Du, Zhenting
Si, Changmei
Li, Youqiang
Wang, Yin
Lu, Jing
author_facet Du, Zhenting
Si, Changmei
Li, Youqiang
Wang, Yin
Lu, Jing
author_sort Du, Zhenting
collection PubMed
description A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield.
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spelling pubmed-33442402012-05-17 Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid Du, Zhenting Si, Changmei Li, Youqiang Wang, Yin Lu, Jing Int J Mol Sci Article A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield. Molecular Diversity Preservation International (MDPI) 2012-04-12 /pmc/articles/PMC3344240/ /pubmed/22606004 http://dx.doi.org/10.3390/ijms13044696 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Du, Zhenting
Si, Changmei
Li, Youqiang
Wang, Yin
Lu, Jing
Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid
title Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid
title_full Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid
title_fullStr Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid
title_full_unstemmed Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid
title_short Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid
title_sort improved synthesis of 5-substituted 1h-tetrazoles via the [3+2] cycloaddition of nitriles and sodium azide catalyzed by silica sulfuric acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344240/
https://www.ncbi.nlm.nih.gov/pubmed/22606004
http://dx.doi.org/10.3390/ijms13044696
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