Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield.

Detalles Bibliográficos
Autores principales: Du, Zhenting, Si, Changmei, Li, Youqiang, Wang, Yin, Lu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344240/
https://www.ncbi.nlm.nih.gov/pubmed/22606004
http://dx.doi.org/10.3390/ijms13044696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344240/
https://www.ncbi.nlm.nih.gov/pubmed/22606004
http://dx.doi.org/10.3390/ijms13044696

Ejemplares similares