Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities

A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data....

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Autores principales: Nayyatip, Sanchai, Thaichana, Pak, Buayairaksa, Mongkol, Tuntiwechapikul, Wirote, Meepowpan, Puttinan, Nuntasaen, Narong, Pompimon, Wilart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344262/
https://www.ncbi.nlm.nih.gov/pubmed/22606026
http://dx.doi.org/10.3390/ijms13045010
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author Nayyatip, Sanchai
Thaichana, Pak
Buayairaksa, Mongkol
Tuntiwechapikul, Wirote
Meepowpan, Puttinan
Nuntasaen, Narong
Pompimon, Wilart
author_facet Nayyatip, Sanchai
Thaichana, Pak
Buayairaksa, Mongkol
Tuntiwechapikul, Wirote
Meepowpan, Puttinan
Nuntasaen, Narong
Pompimon, Wilart
author_sort Nayyatip, Sanchai
collection PubMed
description A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC(50) values of 1.68 and 1.32 μM, respectively.
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spelling pubmed-33442622012-05-17 Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities Nayyatip, Sanchai Thaichana, Pak Buayairaksa, Mongkol Tuntiwechapikul, Wirote Meepowpan, Puttinan Nuntasaen, Narong Pompimon, Wilart Int J Mol Sci Article A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC(50) values of 1.68 and 1.32 μM, respectively. Molecular Diversity Preservation International (MDPI) 2012-04-20 /pmc/articles/PMC3344262/ /pubmed/22606026 http://dx.doi.org/10.3390/ijms13045010 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Nayyatip, Sanchai
Thaichana, Pak
Buayairaksa, Mongkol
Tuntiwechapikul, Wirote
Meepowpan, Puttinan
Nuntasaen, Narong
Pompimon, Wilart
Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities
title Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities
title_full Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities
title_fullStr Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities
title_full_unstemmed Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities
title_short Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities
title_sort aristolactam-type alkaloids from orophea enterocarpa and their cytotoxicities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344262/
https://www.ncbi.nlm.nih.gov/pubmed/22606026
http://dx.doi.org/10.3390/ijms13045010
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