N-(4-Bromo­phen­yl)-2-[(1-cyclo­hexyl­meth­yl-1H-1,2,4-triazol-3-yl)sulfanyl]­acetamide

The title compound, C(17)H(21)BrN(4)OS, was synthesized as a potential reverse transcriptase (RT) inhibitor of the human immunodeficiency virus type 1 (HIV-1). In the molecule, there is an N—H⋯S hydrogen bond making a five-membered ring. In the crystal, mol­ecules are connected into centrosymmetric...

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Detalles Bibliográficos
Autores principales: Wang, Yue-Ping, Yan, Wan-Lu, Guo, Qiong, He, Yan-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2012
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344604/
https://www.ncbi.nlm.nih.gov/pubmed/22590366
http://dx.doi.org/10.1107/S1600536812015991
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author Wang, Yue-Ping
Yan, Wan-Lu
Guo, Qiong
He, Yan-Ping
author_facet Wang, Yue-Ping
Yan, Wan-Lu
Guo, Qiong
He, Yan-Ping
author_sort Wang, Yue-Ping
collection PubMed
description The title compound, C(17)H(21)BrN(4)OS, was synthesized as a potential reverse transcriptase (RT) inhibitor of the human immunodeficiency virus type 1 (HIV-1). In the molecule, there is an N—H⋯S hydrogen bond making a five-membered ring. In the crystal, mol­ecules are connected into centrosymmetric dimers via pairs of N—H⋯N and weak C—H⋯N hydrogen bonds. The crystal structure also features C—H⋯O inter­actions.
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spelling pubmed-33446042012-05-15 N-(4-Bromo­phen­yl)-2-[(1-cyclo­hexyl­meth­yl-1H-1,2,4-triazol-3-yl)sulfanyl]­acetamide Wang, Yue-Ping Yan, Wan-Lu Guo, Qiong He, Yan-Ping Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(17)H(21)BrN(4)OS, was synthesized as a potential reverse transcriptase (RT) inhibitor of the human immunodeficiency virus type 1 (HIV-1). In the molecule, there is an N—H⋯S hydrogen bond making a five-membered ring. In the crystal, mol­ecules are connected into centrosymmetric dimers via pairs of N—H⋯N and weak C—H⋯N hydrogen bonds. The crystal structure also features C—H⋯O inter­actions. International Union of Crystallography 2012-04-21 /pmc/articles/PMC3344604/ /pubmed/22590366 http://dx.doi.org/10.1107/S1600536812015991 Text en © Wang et al. 2012 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Wang, Yue-Ping
Yan, Wan-Lu
Guo, Qiong
He, Yan-Ping
N-(4-Bromo­phen­yl)-2-[(1-cyclo­hexyl­meth­yl-1H-1,2,4-triazol-3-yl)sulfanyl]­acetamide
title N-(4-Bromo­phen­yl)-2-[(1-cyclo­hexyl­meth­yl-1H-1,2,4-triazol-3-yl)sulfanyl]­acetamide
title_full N-(4-Bromo­phen­yl)-2-[(1-cyclo­hexyl­meth­yl-1H-1,2,4-triazol-3-yl)sulfanyl]­acetamide
title_fullStr N-(4-Bromo­phen­yl)-2-[(1-cyclo­hexyl­meth­yl-1H-1,2,4-triazol-3-yl)sulfanyl]­acetamide
title_full_unstemmed N-(4-Bromo­phen­yl)-2-[(1-cyclo­hexyl­meth­yl-1H-1,2,4-triazol-3-yl)sulfanyl]­acetamide
title_short N-(4-Bromo­phen­yl)-2-[(1-cyclo­hexyl­meth­yl-1H-1,2,4-triazol-3-yl)sulfanyl]­acetamide
title_sort n-(4-bromo­phen­yl)-2-[(1-cyclo­hexyl­meth­yl-1h-1,2,4-triazol-3-yl)sulfanyl]­acetamide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344604/
https://www.ncbi.nlm.nih.gov/pubmed/22590366
http://dx.doi.org/10.1107/S1600536812015991
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