The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA

MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing carcinoembryonic antigen (CEA). MEDI-565 binds CEA on cancer cells and CD3 on T cells to induce T-cell mediated killing of cancer cells. To understand t...

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Detalles Bibliográficos
Autores principales: Peng, Li, Oberst, Michael D., Huang, Jiaqi, Brohawn, Philip, Morehouse, Chris, Lekstrom, Kristen, Baeuerle, Patrick A., Wu, Herren, Yao, Yihong, Coats, Steven R., Dall’Acqua, William, Damschroder, Melissa, Hammond, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344869/
https://www.ncbi.nlm.nih.gov/pubmed/22574157
http://dx.doi.org/10.1371/journal.pone.0036412

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