Cargando…

Interference with Oligomerization and Glycosaminoglycan Binding of the Chemokine CCL5 Improves Experimental Liver Injury

BACKGROUND: The chemokine CCL5 is involved in the recruitment of immune cells and a subsequent activation of hepatic stellate cells (HSC) after liver injury. We here investigate whether inhibition of CCL5 oligomerization and glycosaminoglycan binding by a mutated CCL5 protein ((44)AANA(47)-CCL5) has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nellen, Andreas, Heinrichs, Daniel, Berres, Marie-Luise, Sahin, Hacer, Schmitz, Petra, Proudfoot, Amanda E., Trautwein, Christian, Wasmuth, Hermann E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344902/ https://www.ncbi.nlm.nih.gov/pubmed/22574195 http://dx.doi.org/10.1371/journal.pone.0036614

Ejemplares similares

The Chemokine CCL3 Promotes Experimental Liver Fibrosis in Mice
por: Heinrichs, Daniel, et al.
Publicado: (2013)

Chemokines and Glycosaminoglycans
por: Proudfoot, Amanda E. I.
Publicado: (2015)

Biochemical Analysis of Matrix Metalloproteinase Activation of Chemokines CCL15 and CCL23 and Increased Glycosaminoglycan Binding of CCL16
por: Starr, Amanda E., et al.
Publicado: (2012)

The Activity of CCL18 is Principally Mediated through Interaction with Glycosaminoglycans
por: Krohn, Sonja, et al.
Publicado: (2013)

CCL18 Exhibits a Regulatory Role through Inhibition of Receptor and Glycosaminoglycan Binding
por: Krohn, Sonja C., et al.
Publicado: (2013)

Structural Evidence for the Tetrameric Assembly of Chemokine CCL11 and the Glycosaminoglycan Arixtra™
por: Dykstra, Andrew B., et al.
Publicado: (2013)

Chemokine CXCL10 Modulates the Tumor Microenvironment of Fibrosis-Associated Hepatocellular Carcinoma
por: Brandt, Elisa F., et al.
Publicado: (2022)

Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System
por: Proudfoot, Amanda E. I., et al.
Publicado: (2017)

Breast Cancer: Coordinated Regulation of CCL2 Secretion by Intracellular Glycosaminoglycans and Chemokine Motifs()()
por: Lebel-Haziv, Yaeli, et al.
Publicado: (2014)

Platelet Factor 4 Attenuates Experimental Acute Liver Injury in Mice
por: Drescher, Hannah K., et al.
Publicado: (2019)

Interference with Glycosaminoglycan-Chemokine Interactions with a Probe to Alter Leukocyte Recruitment and Inflammation In Vivo
por: Li, Sandra, et al.
Publicado: (2014)

Structural Basis of Chemokine Sequestration by a Tick Chemokine Binding Protein: The Crystal Structure of the Complex between Evasin-1 and CCL3
por: Dias, João M., et al.
Publicado: (2009)

CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signaling
por: Giblin, Sean P., et al.
Publicado: (2023)

Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations
por: Heinrichs, Daniel, et al.
Publicado: (2021)

Targeting Chemokine—Glycosaminoglycan Interactions to Inhibit Inflammation
por: Crijns, Helena, et al.
Publicado: (2020)

Perspectives on the Biological Role of Chemokine:Glycosaminoglycan Interactions
por: Handel, Tracy M., et al.
Publicado: (2020)

Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding
por: Manikowski, Dominique, et al.
Publicado: (2019)

Overexpression of Endoglin Modulates TGF-β1-Signalling Pathways in a Novel Immortalized Mouse Hepatic Stellate Cell Line
por: Meurer, Steffen K., et al.
Publicado: (2013)

Revisiting CCL-type chemokines in breast cancer and its milieu: prominent targetable chemokines, CCL8 and CCL21
por: Unver, Nese
Publicado: (2021)

Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid
por: Wiemuth, Dominik, et al.
Publicado: (2013)

CC chemokines CCL2, CCL3, CCL4 and CCL5 are elevated in osteoporosis patients
por: Farangis, Fatehi, et al.
Publicado: (2017)

Mass spectrometric investigations of the action of hypochlorous acid on monomeric and oligomeric components of glycosaminoglycans
por: Leopold, Jenny, et al.
Publicado: (2023)

The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions
por: Dyer, Douglas P., et al.
Publicado: (2016)

Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization
por: Dyer, Douglas P., et al.
Publicado: (2017)

Chemokines as inflammatory mediators of fibrosis in liver fibrosis
por: Wasmuth, H E
Publicado: (2010)

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions
por: Sawant, Kirti V., et al.
Publicado: (2016)

The Inflammatory Chemokine CCL5 and Cancer Progression
por: Aldinucci, Donatella, et al.
Publicado: (2014)

Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis
por: Yogo, Yurika, et al.
Publicado: (2009)

Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells
por: Didsbury, Alicia, et al.
Publicado: (2011)

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions
por: Joseph, Prem Raj B., et al.
Publicado: (2018)

Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis
por: Palchevskiy, Vyacheslav, et al.
Publicado: (2011)

Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain
por: Biber, Knut, et al.
Publicado: (2014)

Chemokine receptors: multifaceted therapeutic targets
por: Proudfoot, Amanda E. I.
Publicado: (2002)

A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP
por: Goldblatt, Jennifer, et al.
Publicado: (2019)

Expression of Chemokine CCL28 in Ulcerative Colitis Patients
por: Lee, Dong Seok, et al.
Publicado: (2021)

The regulatory network of the chemokine CCL5 in colorectal cancer
por: Zhang, Xin-Feng, et al.
Publicado: (2023)

Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis
por: Queck, Alexander, et al.
Publicado: (2020)

Mechanistic insights into molecular evolution of species-specific differential glycosaminoglycan binding surfaces in growth-related oncogene chemokines
por: Gulati, Khushboo, et al.
Publicado: (2017)

The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity
por: Scheu, Stefanie, et al.
Publicado: (2017)

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils
por: Vantur, Romana, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9fqrksos0bfth3e8bamde464o1