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The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study

Maladaptive impulsivity is a core symptom in various psychiatric disorders. However, there is only limited evidence available on whether different measures of impulsivity represent largely unrelated aspects or a unitary construct. In a cross-species translational study, thirty rats were trained in i...

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Autores principales: Broos, Nienke, Schmaal, Lianne, Wiskerke, Joost, Kostelijk, Lennard, Lam, Thomas, Stoop, Nicky, Weierink, Lonneke, Ham, Jannemieke, de Geus, Eco J. C., Schoffelmeer, Anton N. M., van den Brink, Wim, Veltman, Dick J., de Vries, Taco J., Pattij, Tommy, Goudriaan, Anna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344935/
https://www.ncbi.nlm.nih.gov/pubmed/22574225
http://dx.doi.org/10.1371/journal.pone.0036781
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author Broos, Nienke
Schmaal, Lianne
Wiskerke, Joost
Kostelijk, Lennard
Lam, Thomas
Stoop, Nicky
Weierink, Lonneke
Ham, Jannemieke
de Geus, Eco J. C.
Schoffelmeer, Anton N. M.
van den Brink, Wim
Veltman, Dick J.
de Vries, Taco J.
Pattij, Tommy
Goudriaan, Anna E.
author_facet Broos, Nienke
Schmaal, Lianne
Wiskerke, Joost
Kostelijk, Lennard
Lam, Thomas
Stoop, Nicky
Weierink, Lonneke
Ham, Jannemieke
de Geus, Eco J. C.
Schoffelmeer, Anton N. M.
van den Brink, Wim
Veltman, Dick J.
de Vries, Taco J.
Pattij, Tommy
Goudriaan, Anna E.
author_sort Broos, Nienke
collection PubMed
description Maladaptive impulsivity is a core symptom in various psychiatric disorders. However, there is only limited evidence available on whether different measures of impulsivity represent largely unrelated aspects or a unitary construct. In a cross-species translational study, thirty rats were trained in impulsive choice (delayed reward task) and impulsive action (five-choice serial reaction time task) paradigms. The correlation between those measures was assessed during baseline performance and after pharmacological manipulations with the psychostimulant amphetamine and the norepinephrine reuptake inhibitor atomoxetine. In parallel, to validate the animal data, 101 human subjects performed analogous measures of impulsive choice (delay discounting task, DDT) and impulsive action (immediate and delayed memory task, IMT/DMT). Moreover, all subjects completed the Stop Signal Task (SST, as an additional measure of impulsive action) and filled out the Barratt impulsiveness scale (BIS-11). Correlations between DDT and IMT/DMT were determined and a principal component analysis was performed on all human measures of impulsivity. In both rats and humans measures of impulsive choice and impulsive action did not correlate. In rats the within-subject pharmacological effects of amphetamine and atomoxetine did not correlate between tasks, suggesting distinct underlying neural correlates. Furthermore, in humans, principal component analysis identified three independent factors: (1) self-reported impulsivity (BIS-11); (2) impulsive action (IMT/DMT and SST); (3) impulsive choice (DDT). This is the first study directly comparing aspects of impulsivity using a cross-species translational approach. The present data reveal the non-unitary nature of impulsivity on a behavioral and pharmacological level. Collectively, this warrants a stronger focus on the relative contribution of distinct forms of impulsivity in psychopathology.
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spelling pubmed-33449352012-05-09 The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study Broos, Nienke Schmaal, Lianne Wiskerke, Joost Kostelijk, Lennard Lam, Thomas Stoop, Nicky Weierink, Lonneke Ham, Jannemieke de Geus, Eco J. C. Schoffelmeer, Anton N. M. van den Brink, Wim Veltman, Dick J. de Vries, Taco J. Pattij, Tommy Goudriaan, Anna E. PLoS One Research Article Maladaptive impulsivity is a core symptom in various psychiatric disorders. However, there is only limited evidence available on whether different measures of impulsivity represent largely unrelated aspects or a unitary construct. In a cross-species translational study, thirty rats were trained in impulsive choice (delayed reward task) and impulsive action (five-choice serial reaction time task) paradigms. The correlation between those measures was assessed during baseline performance and after pharmacological manipulations with the psychostimulant amphetamine and the norepinephrine reuptake inhibitor atomoxetine. In parallel, to validate the animal data, 101 human subjects performed analogous measures of impulsive choice (delay discounting task, DDT) and impulsive action (immediate and delayed memory task, IMT/DMT). Moreover, all subjects completed the Stop Signal Task (SST, as an additional measure of impulsive action) and filled out the Barratt impulsiveness scale (BIS-11). Correlations between DDT and IMT/DMT were determined and a principal component analysis was performed on all human measures of impulsivity. In both rats and humans measures of impulsive choice and impulsive action did not correlate. In rats the within-subject pharmacological effects of amphetamine and atomoxetine did not correlate between tasks, suggesting distinct underlying neural correlates. Furthermore, in humans, principal component analysis identified three independent factors: (1) self-reported impulsivity (BIS-11); (2) impulsive action (IMT/DMT and SST); (3) impulsive choice (DDT). This is the first study directly comparing aspects of impulsivity using a cross-species translational approach. The present data reveal the non-unitary nature of impulsivity on a behavioral and pharmacological level. Collectively, this warrants a stronger focus on the relative contribution of distinct forms of impulsivity in psychopathology. Public Library of Science 2012-05-04 /pmc/articles/PMC3344935/ /pubmed/22574225 http://dx.doi.org/10.1371/journal.pone.0036781 Text en Broos et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Broos, Nienke
Schmaal, Lianne
Wiskerke, Joost
Kostelijk, Lennard
Lam, Thomas
Stoop, Nicky
Weierink, Lonneke
Ham, Jannemieke
de Geus, Eco J. C.
Schoffelmeer, Anton N. M.
van den Brink, Wim
Veltman, Dick J.
de Vries, Taco J.
Pattij, Tommy
Goudriaan, Anna E.
The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study
title The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study
title_full The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study
title_fullStr The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study
title_full_unstemmed The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study
title_short The Relationship between Impulsive Choice and Impulsive Action: A Cross-Species Translational Study
title_sort relationship between impulsive choice and impulsive action: a cross-species translational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344935/
https://www.ncbi.nlm.nih.gov/pubmed/22574225
http://dx.doi.org/10.1371/journal.pone.0036781
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