How Ubiquitin Unfolds after Transfer into the Gas Phase

The structural evolution of ubiquitin after transfer into the gas phase was studied by electron capture dissociation. Site-specific fragment yields show that ubiquitin’s solution fold is overall unstable in the gas phase, but unfolding caused by loss of solvent is slowest in regions stabilized by sa...

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Detalles Bibliográficos
Autores principales: Skinner, Owen S., McLafferty, Fred W., Breuker, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345118/
https://www.ncbi.nlm.nih.gov/pubmed/22476890
http://dx.doi.org/10.1007/s13361-012-0370-6
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author Skinner, Owen S.
McLafferty, Fred W.
Breuker, Kathrin
author_facet Skinner, Owen S.
McLafferty, Fred W.
Breuker, Kathrin
author_sort Skinner, Owen S.
collection PubMed
description The structural evolution of ubiquitin after transfer into the gas phase was studied by electron capture dissociation. Site-specific fragment yields show that ubiquitin’s solution fold is overall unstable in the gas phase, but unfolding caused by loss of solvent is slowest in regions stabilized by salt bridges.
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spelling pubmed-33451182012-05-24 How Ubiquitin Unfolds after Transfer into the Gas Phase Skinner, Owen S. McLafferty, Fred W. Breuker, Kathrin J Am Soc Mass Spectrom Short Communication The structural evolution of ubiquitin after transfer into the gas phase was studied by electron capture dissociation. Site-specific fragment yields show that ubiquitin’s solution fold is overall unstable in the gas phase, but unfolding caused by loss of solvent is slowest in regions stabilized by salt bridges. Springer-Verlag 2012-04-03 2012 /pmc/articles/PMC3345118/ /pubmed/22476890 http://dx.doi.org/10.1007/s13361-012-0370-6 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Short Communication
Skinner, Owen S.
McLafferty, Fred W.
Breuker, Kathrin
How Ubiquitin Unfolds after Transfer into the Gas Phase
title How Ubiquitin Unfolds after Transfer into the Gas Phase
title_full How Ubiquitin Unfolds after Transfer into the Gas Phase
title_fullStr How Ubiquitin Unfolds after Transfer into the Gas Phase
title_full_unstemmed How Ubiquitin Unfolds after Transfer into the Gas Phase
title_short How Ubiquitin Unfolds after Transfer into the Gas Phase
title_sort how ubiquitin unfolds after transfer into the gas phase
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345118/
https://www.ncbi.nlm.nih.gov/pubmed/22476890
http://dx.doi.org/10.1007/s13361-012-0370-6
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