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Significance of the Intima-Media Thickness of Carotid and Thoracic Aorta in Coronary Artery Disease in the South Indian Population
BACKGROUND: Ultrasound detected intima-media thickness (IMT) of the carotid artery and thoracic aorta are possible screening tests to assess the risk of coronary artery disease (CAD) in asymptomatic individuals. OBJECTIVE: Aim of the study was to assess the utility of carotid and aortic IMT as a pre...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345149/ https://www.ncbi.nlm.nih.gov/pubmed/22574240 http://dx.doi.org/10.4103/1995-705X.90901 |
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author | Meenakshisundaram, Ramachandran Devidutta, Soumen Michaels, Andrew D. Senthilkumaran, Subramanian Rajendiran, Chinnasamy Thirumalaikolundusubramanian, Ponniah |
author_facet | Meenakshisundaram, Ramachandran Devidutta, Soumen Michaels, Andrew D. Senthilkumaran, Subramanian Rajendiran, Chinnasamy Thirumalaikolundusubramanian, Ponniah |
author_sort | Meenakshisundaram, Ramachandran |
collection | PubMed |
description | BACKGROUND: Ultrasound detected intima-media thickness (IMT) of the carotid artery and thoracic aorta are possible screening tests to assess the risk of coronary artery disease (CAD) in asymptomatic individuals. OBJECTIVE: Aim of the study was to assess the utility of carotid and aortic IMT as a predictor of CAD and to assess the extent of IMT with severity of CAD in a South Indian population. PATIENTS AND METHODS: A cross-sectional and analytical study was carried out among 40 cases, who had angiographic evidence of CAD against 30 healthy control subjects with a normal treadmill test. At plaque-free regions, the carotid IMT was evaluated by B-mode ultrasonography and thoracic aorta IMT was evaluated by trans-esophageal echocardiography (TEE). The significance of difference in means between two groups was analyzed using one-way ANOVA F-test and the significance of difference in proportions by Chi-square test. Multiple comparisons were done by Bonferroni t test. The correlation between IMT and severity of CAD was assessed by Spearman's method. RESULTS: There were 38 males and 2 females among cases with age 51.7 ± 8.3 years, and 28 males and 2 females among control subjects with age 52.2 ± 7.1 years. Increased carotid IMT was noted among 24 cases and 2 control subjects, and the association was significant for CAD [P < 0.001, Chi-square = 20.89, odds ratio (OR) = 21.00, and 95% confidence interval (CI) = 4.78-89.59]. Similarly, 19 cases and one control subject had abnormal IMT with positive correlation for CAD (P < 0.001, Chi-square = 16.39, OR = 28.24, and 95% CI = 4.06-163.21). There was no association between IMT and diabetes, hypertension, or smoking; however, IMT was significantly associated with age and dyslipidemia. Also, there was no correlation between extent of IMT and severity of CAD. CONCLUSIONS: IMT of the carotid and thoracic aorta is strongly associated with risk of CAD in a South Indian population, and may be used as a non-invasive screening tool for coronary atherosclerosis in resource-limited settings. The presence of dyslipidemia influenced IMT and may be used as a tool to follow patients on hypolipidemic drugs. |
format | Online Article Text |
id | pubmed-3345149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33451492012-05-09 Significance of the Intima-Media Thickness of Carotid and Thoracic Aorta in Coronary Artery Disease in the South Indian Population Meenakshisundaram, Ramachandran Devidutta, Soumen Michaels, Andrew D. Senthilkumaran, Subramanian Rajendiran, Chinnasamy Thirumalaikolundusubramanian, Ponniah Heart Views Original Article BACKGROUND: Ultrasound detected intima-media thickness (IMT) of the carotid artery and thoracic aorta are possible screening tests to assess the risk of coronary artery disease (CAD) in asymptomatic individuals. OBJECTIVE: Aim of the study was to assess the utility of carotid and aortic IMT as a predictor of CAD and to assess the extent of IMT with severity of CAD in a South Indian population. PATIENTS AND METHODS: A cross-sectional and analytical study was carried out among 40 cases, who had angiographic evidence of CAD against 30 healthy control subjects with a normal treadmill test. At plaque-free regions, the carotid IMT was evaluated by B-mode ultrasonography and thoracic aorta IMT was evaluated by trans-esophageal echocardiography (TEE). The significance of difference in means between two groups was analyzed using one-way ANOVA F-test and the significance of difference in proportions by Chi-square test. Multiple comparisons were done by Bonferroni t test. The correlation between IMT and severity of CAD was assessed by Spearman's method. RESULTS: There were 38 males and 2 females among cases with age 51.7 ± 8.3 years, and 28 males and 2 females among control subjects with age 52.2 ± 7.1 years. Increased carotid IMT was noted among 24 cases and 2 control subjects, and the association was significant for CAD [P < 0.001, Chi-square = 20.89, odds ratio (OR) = 21.00, and 95% confidence interval (CI) = 4.78-89.59]. Similarly, 19 cases and one control subject had abnormal IMT with positive correlation for CAD (P < 0.001, Chi-square = 16.39, OR = 28.24, and 95% CI = 4.06-163.21). There was no association between IMT and diabetes, hypertension, or smoking; however, IMT was significantly associated with age and dyslipidemia. Also, there was no correlation between extent of IMT and severity of CAD. CONCLUSIONS: IMT of the carotid and thoracic aorta is strongly associated with risk of CAD in a South Indian population, and may be used as a non-invasive screening tool for coronary atherosclerosis in resource-limited settings. The presence of dyslipidemia influenced IMT and may be used as a tool to follow patients on hypolipidemic drugs. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3345149/ /pubmed/22574240 http://dx.doi.org/10.4103/1995-705X.90901 Text en Copyright: © Heart Views http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Meenakshisundaram, Ramachandran Devidutta, Soumen Michaels, Andrew D. Senthilkumaran, Subramanian Rajendiran, Chinnasamy Thirumalaikolundusubramanian, Ponniah Significance of the Intima-Media Thickness of Carotid and Thoracic Aorta in Coronary Artery Disease in the South Indian Population |
title | Significance of the Intima-Media Thickness of Carotid and Thoracic Aorta in Coronary Artery Disease in the South Indian Population |
title_full | Significance of the Intima-Media Thickness of Carotid and Thoracic Aorta in Coronary Artery Disease in the South Indian Population |
title_fullStr | Significance of the Intima-Media Thickness of Carotid and Thoracic Aorta in Coronary Artery Disease in the South Indian Population |
title_full_unstemmed | Significance of the Intima-Media Thickness of Carotid and Thoracic Aorta in Coronary Artery Disease in the South Indian Population |
title_short | Significance of the Intima-Media Thickness of Carotid and Thoracic Aorta in Coronary Artery Disease in the South Indian Population |
title_sort | significance of the intima-media thickness of carotid and thoracic aorta in coronary artery disease in the south indian population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345149/ https://www.ncbi.nlm.nih.gov/pubmed/22574240 http://dx.doi.org/10.4103/1995-705X.90901 |
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