Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes

In human intestinal epithelial crypt (HIEC) cells, the PI3-K/Akt-1 pathway is crucial for the promotion of cell survival and suppression of anoikis. Class I PI3-K consists of a complex formed by a catalytic (C) and regulatory (R) subunit. Three R (p85α, β, and p55γ) and four C (p110α, β, γ and δ) is...

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Detalles Bibliográficos
Autores principales: Beauséjour, Marco, Noël, Dominique, Thibodeau, Sonya, Bouchard, Véronique, Harnois, Charlène, Beaulieu, Jean-François, Demers, Marie-Josée, Vachon, Pierre H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345181/
https://www.ncbi.nlm.nih.gov/pubmed/22402981
http://dx.doi.org/10.1007/s10495-012-0713-6

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