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The role of tiotropium in the management of asthma
Asthma is a chronic respiratory disease characterized by reversible airway obstruction that is secondary to an allergic inflammation and excessive smooth muscle contraction. Cholinergic signals were known to contribute significantly to the pathophysiology of asthma. However, the use of anti-choliner...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345323/ https://www.ncbi.nlm.nih.gov/pubmed/22701860 http://dx.doi.org/10.5415/apallergy.2012.2.2.109 |
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author | Park, Heung-Woo |
author_facet | Park, Heung-Woo |
author_sort | Park, Heung-Woo |
collection | PubMed |
description | Asthma is a chronic respiratory disease characterized by reversible airway obstruction that is secondary to an allergic inflammation and excessive smooth muscle contraction. Cholinergic signals were known to contribute significantly to the pathophysiology of asthma. However, the use of anti-cholinergic agents in asthma has been justified only in acute asthma exacerbations, until tiotropium bromide, a long-acting anti-cholinergic agent was introduced. Recent reports showing a promising role of tiotropium in the treatment of asthma have aroused interest of the use of anti-cholinergic agent for the management of asthma. This report describes pharmacological characteristics, potential effects on inflammatory cells, and the current status of tiotropium in the treatment of asthma. |
format | Online Article Text |
id | pubmed-3345323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-33453232012-06-14 The role of tiotropium in the management of asthma Park, Heung-Woo Asia Pac Allergy Current Review Asthma is a chronic respiratory disease characterized by reversible airway obstruction that is secondary to an allergic inflammation and excessive smooth muscle contraction. Cholinergic signals were known to contribute significantly to the pathophysiology of asthma. However, the use of anti-cholinergic agents in asthma has been justified only in acute asthma exacerbations, until tiotropium bromide, a long-acting anti-cholinergic agent was introduced. Recent reports showing a promising role of tiotropium in the treatment of asthma have aroused interest of the use of anti-cholinergic agent for the management of asthma. This report describes pharmacological characteristics, potential effects on inflammatory cells, and the current status of tiotropium in the treatment of asthma. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2012-04 2012-04-30 /pmc/articles/PMC3345323/ /pubmed/22701860 http://dx.doi.org/10.5415/apallergy.2012.2.2.109 Text en Copyright © 2012. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Current Review Park, Heung-Woo The role of tiotropium in the management of asthma |
title | The role of tiotropium in the management of asthma |
title_full | The role of tiotropium in the management of asthma |
title_fullStr | The role of tiotropium in the management of asthma |
title_full_unstemmed | The role of tiotropium in the management of asthma |
title_short | The role of tiotropium in the management of asthma |
title_sort | role of tiotropium in the management of asthma |
topic | Current Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345323/ https://www.ncbi.nlm.nih.gov/pubmed/22701860 http://dx.doi.org/10.5415/apallergy.2012.2.2.109 |
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