Stress Studies of Tenofovir Disoproxil Fumarate by HPTLC in Bulk Drug and Pharmaceutical Formulation

A stability-indicating high-performance thin-layer chromatographic (HPTLC) method for determination of tenofovir disoproxil fumarate in bulk drug and in tablet has been developed and validated. The mobile phase selected was chloroform : methanol (9.0 : 1.0, v/v) with ultraviolet (UV) detection at 26...

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Detalles Bibliográficos
Autores principales: Havele, Shweta, Dhaneshwar, Sunil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345998/
https://www.ncbi.nlm.nih.gov/pubmed/22606065
http://dx.doi.org/10.1100/2012/894136
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author Havele, Shweta
Dhaneshwar, Sunil R.
author_facet Havele, Shweta
Dhaneshwar, Sunil R.
author_sort Havele, Shweta
collection PubMed
description A stability-indicating high-performance thin-layer chromatographic (HPTLC) method for determination of tenofovir disoproxil fumarate in bulk drug and in tablet has been developed and validated. The mobile phase selected was chloroform : methanol (9.0 : 1.0, v/v) with ultraviolet (UV) detection at 260 nm. The retention factor was found to be 0.49 ± 0.03 with correlation coefficients of 0.9994 in the range 300–1500 ng/spot and with an accuracy of 99.25%. Method had the potential to determine tenofovir disoproxil fumarate from tablet without any interference, and it was a stability-indicating one.
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spelling pubmed-33459982012-05-17 Stress Studies of Tenofovir Disoproxil Fumarate by HPTLC in Bulk Drug and Pharmaceutical Formulation Havele, Shweta Dhaneshwar, Sunil R. ScientificWorldJournal Research Article A stability-indicating high-performance thin-layer chromatographic (HPTLC) method for determination of tenofovir disoproxil fumarate in bulk drug and in tablet has been developed and validated. The mobile phase selected was chloroform : methanol (9.0 : 1.0, v/v) with ultraviolet (UV) detection at 260 nm. The retention factor was found to be 0.49 ± 0.03 with correlation coefficients of 0.9994 in the range 300–1500 ng/spot and with an accuracy of 99.25%. Method had the potential to determine tenofovir disoproxil fumarate from tablet without any interference, and it was a stability-indicating one. The Scientific World Journal 2012-04-19 /pmc/articles/PMC3345998/ /pubmed/22606065 http://dx.doi.org/10.1100/2012/894136 Text en Copyright © 2012 S. Havele and S. R. Dhaneshwar. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Havele, Shweta
Dhaneshwar, Sunil R.
Stress Studies of Tenofovir Disoproxil Fumarate by HPTLC in Bulk Drug and Pharmaceutical Formulation
title Stress Studies of Tenofovir Disoproxil Fumarate by HPTLC in Bulk Drug and Pharmaceutical Formulation
title_full Stress Studies of Tenofovir Disoproxil Fumarate by HPTLC in Bulk Drug and Pharmaceutical Formulation
title_fullStr Stress Studies of Tenofovir Disoproxil Fumarate by HPTLC in Bulk Drug and Pharmaceutical Formulation
title_full_unstemmed Stress Studies of Tenofovir Disoproxil Fumarate by HPTLC in Bulk Drug and Pharmaceutical Formulation
title_short Stress Studies of Tenofovir Disoproxil Fumarate by HPTLC in Bulk Drug and Pharmaceutical Formulation
title_sort stress studies of tenofovir disoproxil fumarate by hptlc in bulk drug and pharmaceutical formulation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345998/
https://www.ncbi.nlm.nih.gov/pubmed/22606065
http://dx.doi.org/10.1100/2012/894136
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