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Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD)
There are many unanswered questions about cerebral lateralization. In particular, it remains unclear which aspects of language and nonverbal ability are lateralized, whether there are any disadvantages associated with atypical patterns of cerebral lateralization, and whether cerebral lateralization...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MyJove Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346060/ https://www.ncbi.nlm.nih.gov/pubmed/20972398 http://dx.doi.org/10.3791/2161 |
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author | Bishop, Dorothy V. M. Badcock, Nicholas A. Holt, Georgina |
author_facet | Bishop, Dorothy V. M. Badcock, Nicholas A. Holt, Georgina |
author_sort | Bishop, Dorothy V. M. |
collection | PubMed |
description | There are many unanswered questions about cerebral lateralization. In particular, it remains unclear which aspects of language and nonverbal ability are lateralized, whether there are any disadvantages associated with atypical patterns of cerebral lateralization, and whether cerebral lateralization develops with age. In the past, researchers interested in these questions tended to use handedness as a proxy measure for cerebral lateralization, but this is unsatisfactory because handedness is only a weak and indirect indicator of laterality of cognitive functions(1). Other methods, such as fMRI, are expensive for large-scale studies, and not always feasible with children(2). Here we will describe the use of functional transcranial Doppler ultrasound (fTCD) as a cost-effective, non-invasive and reliable method for assessing cerebral lateralization. The procedure involves measuring blood flow in the middle cerebral artery via an ultrasound probe placed just in front of the ear. Our work builds on work by Rune Aaslid, who co-introduced TCD in 1982, and Stefan Knecht, Michael Deppe and their colleagues at the University of Münster, who pioneered the use of simultaneous measurements of left- and right middle cerebral artery blood flow, and devised a method of correcting for heart beat activity. This made it possible to see a clear increase in left-sided blood flow during language generation, with lateralization agreeing well with that obtained using other methods(3). The middle cerebral artery has a very wide vascular territory (see Figure 1) and the method does not provide useful information about localization within a hemisphere. Our experience suggests it is particularly sensitive to tasks that involve explicit or implicit speech production. The 'gold standard' task is a word generation task (e.g. think of as many words as you can that begin with the letter 'B') (4), but this is not suitable for young children and others with limited literacy skills. Compared with other brain imaging methods, fTCD is relatively unaffected by movement artefacts from speaking, and so we are able to get a reliable result from tasks that involve describing pictures aloud(5,6). Accordingly, we have developed a child-friendly task that involves looking at video-clips that tell a story, and then describing what was seen. |
format | Online Article Text |
id | pubmed-3346060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MyJove Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33460602012-05-08 Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD) Bishop, Dorothy V. M. Badcock, Nicholas A. Holt, Georgina J Vis Exp Neuroscience There are many unanswered questions about cerebral lateralization. In particular, it remains unclear which aspects of language and nonverbal ability are lateralized, whether there are any disadvantages associated with atypical patterns of cerebral lateralization, and whether cerebral lateralization develops with age. In the past, researchers interested in these questions tended to use handedness as a proxy measure for cerebral lateralization, but this is unsatisfactory because handedness is only a weak and indirect indicator of laterality of cognitive functions(1). Other methods, such as fMRI, are expensive for large-scale studies, and not always feasible with children(2). Here we will describe the use of functional transcranial Doppler ultrasound (fTCD) as a cost-effective, non-invasive and reliable method for assessing cerebral lateralization. The procedure involves measuring blood flow in the middle cerebral artery via an ultrasound probe placed just in front of the ear. Our work builds on work by Rune Aaslid, who co-introduced TCD in 1982, and Stefan Knecht, Michael Deppe and their colleagues at the University of Münster, who pioneered the use of simultaneous measurements of left- and right middle cerebral artery blood flow, and devised a method of correcting for heart beat activity. This made it possible to see a clear increase in left-sided blood flow during language generation, with lateralization agreeing well with that obtained using other methods(3). The middle cerebral artery has a very wide vascular territory (see Figure 1) and the method does not provide useful information about localization within a hemisphere. Our experience suggests it is particularly sensitive to tasks that involve explicit or implicit speech production. The 'gold standard' task is a word generation task (e.g. think of as many words as you can that begin with the letter 'B') (4), but this is not suitable for young children and others with limited literacy skills. Compared with other brain imaging methods, fTCD is relatively unaffected by movement artefacts from speaking, and so we are able to get a reliable result from tasks that involve describing pictures aloud(5,6). Accordingly, we have developed a child-friendly task that involves looking at video-clips that tell a story, and then describing what was seen. MyJove Corporation 2010-09-27 /pmc/articles/PMC3346060/ /pubmed/20972398 http://dx.doi.org/10.3791/2161 Text en Copyright © 2010, Journal of Visualized Experiments http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visithttp://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Neuroscience Bishop, Dorothy V. M. Badcock, Nicholas A. Holt, Georgina Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD) |
title | Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD) |
title_full | Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD) |
title_fullStr | Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD) |
title_full_unstemmed | Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD) |
title_short | Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD) |
title_sort | assessment of cerebral lateralization in children using functional transcranial doppler ultrasound (ftcd) |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346060/ https://www.ncbi.nlm.nih.gov/pubmed/20972398 http://dx.doi.org/10.3791/2161 |
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