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Osteopontin Plays a Critical Role in Interstitial Fibrosis but Not Glomerular Sclerosis in Diabetic Nephropathy
BACKGROUND/AIMS: Osteopontin (OPN) has been implicated in the pathology of several renal conditions. The aim of this study was to clarify the roles of OPN in diabetic nephropathy. METHODS: Diabetes mellitus (DM) was induced in wild-type (WT) and OPN knockout (KO) mice by injecting streptozotocin. Th...
Autores principales: | Nagao, Tomoaki, Okura, Takafumi, Irita, Jun, Jotoku, Masanori, Enomoto, Daijiro, Desilva, Veena Rasika, Miyoshi, Ken-ichi, Kurata, Mie, Matsui, Yutaka, Uede, Toshimitsu, Higaki, Jitsuo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346163/ https://www.ncbi.nlm.nih.gov/pubmed/22619671 http://dx.doi.org/10.1159/000337330 |
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