Liver-specific microRNA-122: Biogenesis and function

microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a t...

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Detalles Bibliográficos
Autor principal: Jopling, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
RNA Families
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346312/
https://www.ncbi.nlm.nih.gov/pubmed/22258222
http://dx.doi.org/10.4161/rna.18827
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author Jopling, Catherine
author_facet Jopling, Catherine
author_sort Jopling, Catherine
collection PubMed
description microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122.
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spelling pubmed-33463122012-05-08 Liver-specific microRNA-122: Biogenesis and function Jopling, Catherine RNA Biol RNA Families microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122. Landes Bioscience 2012-02-01 /pmc/articles/PMC3346312/ /pubmed/22258222 http://dx.doi.org/10.4161/rna.18827 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle RNA Families
Jopling, Catherine
Liver-specific microRNA-122: Biogenesis and function
title Liver-specific microRNA-122: Biogenesis and function
title_full Liver-specific microRNA-122: Biogenesis and function
title_fullStr Liver-specific microRNA-122: Biogenesis and function
title_full_unstemmed Liver-specific microRNA-122: Biogenesis and function
title_short Liver-specific microRNA-122: Biogenesis and function
title_sort liver-specific microrna-122: biogenesis and function
topic RNA Families
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346312/
https://www.ncbi.nlm.nih.gov/pubmed/22258222
http://dx.doi.org/10.4161/rna.18827
work_keys_str_mv AT joplingcatherine liverspecificmicrorna122biogenesisandfunction

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