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The Prevalence of Immunologic Injury in Renal Allograft Recipients with De Novo Proteinuria
Post-transplant proteinuria is a common complication after renal transplantation; it is associated with reduced graft and recipient survival. However, the prevalence of histological causes has been reported with considerable variation. A clinico-pathological re-evaluation of post-transplant proteinu...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346732/ https://www.ncbi.nlm.nih.gov/pubmed/22586485 http://dx.doi.org/10.1371/journal.pone.0036654 |
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author | Sun, Qiquan Jiang, Song Li, Xue Huang, Xianghua Xie, Kenan Cheng, Dongrui Chen, Jinsong Ji, Shuming Wen, Jiqiu Zhang, Mingchao Zeng, Caihong Liu, Zhihong |
author_facet | Sun, Qiquan Jiang, Song Li, Xue Huang, Xianghua Xie, Kenan Cheng, Dongrui Chen, Jinsong Ji, Shuming Wen, Jiqiu Zhang, Mingchao Zeng, Caihong Liu, Zhihong |
author_sort | Sun, Qiquan |
collection | PubMed |
description | Post-transplant proteinuria is a common complication after renal transplantation; it is associated with reduced graft and recipient survival. However, the prevalence of histological causes has been reported with considerable variation. A clinico-pathological re-evaluation of post-transplant proteinuria is necessary, especially after dismissal of the term “chronic allograft nephropathy,” which had been considered to be an important cause of proteinuria. Moreover, urinary protein can promote interstitial inflammation in native kidney, whether this occurs in renal allograft remains unknown. Factors that affect the graft outcome in patients with proteinuria also remain unclear. Here we collected 98 cases of renal allograft recipients who developed proteinuria after transplant, histological features were characterized using Banff scoring system. Cox proportional hazard regression models were used for graft survival predictors. We found that transplant glomerulopathy was the leading (40.8%) cause of post-transplant proteinuria. Immunological causes, including transplant glomerulopathy, acute rejection, and chronic rejection accounted for the majority of all pathological causes of proteinuria. Nevertheless, almost all patients that developed proteinuria had immunological lesions in the graft, especially for interstitial inflammation. Intraglomerular C3 deposition was unexpectedly correlated with the severity of proteinuria. Moreover, the severity of interstitial inflammation was an independent risk factor for graft loss, while high level of hemoglobin was a protective factor for graft survival. This study revealed a predominance of immunological parameters in renal allografts with post-transplant proteinuria. These parameters not only correlate with the severity of proteinuria, but also with the outcome of the graft. |
format | Online Article Text |
id | pubmed-3346732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33467322012-05-14 The Prevalence of Immunologic Injury in Renal Allograft Recipients with De Novo Proteinuria Sun, Qiquan Jiang, Song Li, Xue Huang, Xianghua Xie, Kenan Cheng, Dongrui Chen, Jinsong Ji, Shuming Wen, Jiqiu Zhang, Mingchao Zeng, Caihong Liu, Zhihong PLoS One Research Article Post-transplant proteinuria is a common complication after renal transplantation; it is associated with reduced graft and recipient survival. However, the prevalence of histological causes has been reported with considerable variation. A clinico-pathological re-evaluation of post-transplant proteinuria is necessary, especially after dismissal of the term “chronic allograft nephropathy,” which had been considered to be an important cause of proteinuria. Moreover, urinary protein can promote interstitial inflammation in native kidney, whether this occurs in renal allograft remains unknown. Factors that affect the graft outcome in patients with proteinuria also remain unclear. Here we collected 98 cases of renal allograft recipients who developed proteinuria after transplant, histological features were characterized using Banff scoring system. Cox proportional hazard regression models were used for graft survival predictors. We found that transplant glomerulopathy was the leading (40.8%) cause of post-transplant proteinuria. Immunological causes, including transplant glomerulopathy, acute rejection, and chronic rejection accounted for the majority of all pathological causes of proteinuria. Nevertheless, almost all patients that developed proteinuria had immunological lesions in the graft, especially for interstitial inflammation. Intraglomerular C3 deposition was unexpectedly correlated with the severity of proteinuria. Moreover, the severity of interstitial inflammation was an independent risk factor for graft loss, while high level of hemoglobin was a protective factor for graft survival. This study revealed a predominance of immunological parameters in renal allografts with post-transplant proteinuria. These parameters not only correlate with the severity of proteinuria, but also with the outcome of the graft. Public Library of Science 2012-05-07 /pmc/articles/PMC3346732/ /pubmed/22586485 http://dx.doi.org/10.1371/journal.pone.0036654 Text en Sun et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Sun, Qiquan Jiang, Song Li, Xue Huang, Xianghua Xie, Kenan Cheng, Dongrui Chen, Jinsong Ji, Shuming Wen, Jiqiu Zhang, Mingchao Zeng, Caihong Liu, Zhihong The Prevalence of Immunologic Injury in Renal Allograft Recipients with De Novo Proteinuria |
title | The Prevalence of Immunologic Injury in Renal Allograft Recipients with De Novo Proteinuria |
title_full | The Prevalence of Immunologic Injury in Renal Allograft Recipients with De Novo Proteinuria |
title_fullStr | The Prevalence of Immunologic Injury in Renal Allograft Recipients with De Novo Proteinuria |
title_full_unstemmed | The Prevalence of Immunologic Injury in Renal Allograft Recipients with De Novo Proteinuria |
title_short | The Prevalence of Immunologic Injury in Renal Allograft Recipients with De Novo Proteinuria |
title_sort | prevalence of immunologic injury in renal allograft recipients with de novo proteinuria |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346732/ https://www.ncbi.nlm.nih.gov/pubmed/22586485 http://dx.doi.org/10.1371/journal.pone.0036654 |
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