EGFR-Mediated Carcinoma Cell Metastasis Mediated by Integrin αvβ5 Depends on Activation of c-Src and Cleavage of MUC1

Receptor tyrosine kinases and integrins play an essential role in tumor cell invasion and metastasis. We previously showed that EGF and other growth factors induce human carcinoma cell invasion and metastasis mediated by integrin αvβ5 that is prevented by Src blockade [1]. MUC1, a transmembrane glyc...

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Detalles Bibliográficos
Autores principales: Lau, Steven K. M., Shields, David J., Murphy, Eric A., Desgrosellier, Jay S., Anand, Sudarshan, Huang, Miller, Kato, Shumei, Lim, Ssang-Taek, Weis, Sara M., Stupack, Dwayne G., Schlaepfer, David D., Cheresh, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346745/
https://www.ncbi.nlm.nih.gov/pubmed/22586492
http://dx.doi.org/10.1371/journal.pone.0036753

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