Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment

Neutrophil migration is vital for immunity and precedes effector functions such as pathogen killing. Here, we report that this process is regulated by the Rab27a GTPase, a protein known to control granule exocytosis. Rab27a-deficient (Rab27a KO) neutrophils exhibit migration defects in vitro and in...

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Detalles Bibliográficos
Autores principales: Singh, Rajesh K., Liao, Wenjia, Tracey-White, Dhani, Recchi, Chiara, Tolmachova, Tanya, Rankin, Sara M., Hume, Alistair N., Seabra, Miguel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Company of Biologists 2012
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346826/
https://www.ncbi.nlm.nih.gov/pubmed/22375060
http://dx.doi.org/10.1242/jcs.100438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346826/
https://www.ncbi.nlm.nih.gov/pubmed/22375060
http://dx.doi.org/10.1242/jcs.100438

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