Cargando…
Changes in Transepidermal Water Loss and Skin Hydration according to Expression of Aquaporin-3 in Psoriasis
BACKGROUND: Aquaporins (AQPs) are a family of water transporting proteins present in many mammalian epithelial and endothelial cell types. Among the AQPs, AQP3 is known to be a water/glycerol transporter expressed in human skin. OBJECTIVE: The relationship between the expression level of AQP3 and tr...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Dermatological Association; The Korean Society for Investigative Dermatology
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346907/ https://www.ncbi.nlm.nih.gov/pubmed/22577267 http://dx.doi.org/10.5021/ad.2012.24.2.168 |
_version_ | 1782232242319261696 |
---|---|
author | Lee, Young Je, Young-Jin Lee, Sang-Sin Li, Zheng Jun Choi, Dae-Kyoung Kwon, Yoo-Bin Sohn, Kyung-Cheol Im, Myung Seo, Young Joon Lee, Jeung Hoon |
author_facet | Lee, Young Je, Young-Jin Lee, Sang-Sin Li, Zheng Jun Choi, Dae-Kyoung Kwon, Yoo-Bin Sohn, Kyung-Cheol Im, Myung Seo, Young Joon Lee, Jeung Hoon |
author_sort | Lee, Young |
collection | PubMed |
description | BACKGROUND: Aquaporins (AQPs) are a family of water transporting proteins present in many mammalian epithelial and endothelial cell types. Among the AQPs, AQP3 is known to be a water/glycerol transporter expressed in human skin. OBJECTIVE: The relationship between the expression level of AQP3 and transpidermal water loss (TEWL) in the lesional and peri-lesional skin of psoriasis-affected patients, and skin hydration in the lesional and peri-lesional skin of psoriasis patients, was investigated. METHODS: The expression of AQP3 in psoriasis-affected and healthy control skin was determined using immunohistochemical and immunofluroscence staining. TEWL and skin hydration were measured using a Tewameter® TM210 (Courage & Khazaka, Cologne, Germany) and a Corneometer® CM 820 (Courage & Khazaka), respectively. RESULTS: AQP3 was mainly expressed in the plasma membrane of stratum corneum and the stratum spinosum in normal epidermis. Unlike the normal epidermis, AQP3 showed decreased expression in the lesional and peri-lesional epidermis of psoriasis. TEWL was increased, and skin hydration was decreased, in the lesional and peri-lesional skin of psoriasis patients, compared with the healthy control sample. CONCLUSION: Although various factors contribute to reduced skin hydration in the lesional and peri-lesional skin of psoriasis, AQP3 appears to be a key factor in the skin dehydration of psoriasis-affected skin. |
format | Online Article Text |
id | pubmed-3346907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-33469072012-05-10 Changes in Transepidermal Water Loss and Skin Hydration according to Expression of Aquaporin-3 in Psoriasis Lee, Young Je, Young-Jin Lee, Sang-Sin Li, Zheng Jun Choi, Dae-Kyoung Kwon, Yoo-Bin Sohn, Kyung-Cheol Im, Myung Seo, Young Joon Lee, Jeung Hoon Ann Dermatol Original Article BACKGROUND: Aquaporins (AQPs) are a family of water transporting proteins present in many mammalian epithelial and endothelial cell types. Among the AQPs, AQP3 is known to be a water/glycerol transporter expressed in human skin. OBJECTIVE: The relationship between the expression level of AQP3 and transpidermal water loss (TEWL) in the lesional and peri-lesional skin of psoriasis-affected patients, and skin hydration in the lesional and peri-lesional skin of psoriasis patients, was investigated. METHODS: The expression of AQP3 in psoriasis-affected and healthy control skin was determined using immunohistochemical and immunofluroscence staining. TEWL and skin hydration were measured using a Tewameter® TM210 (Courage & Khazaka, Cologne, Germany) and a Corneometer® CM 820 (Courage & Khazaka), respectively. RESULTS: AQP3 was mainly expressed in the plasma membrane of stratum corneum and the stratum spinosum in normal epidermis. Unlike the normal epidermis, AQP3 showed decreased expression in the lesional and peri-lesional epidermis of psoriasis. TEWL was increased, and skin hydration was decreased, in the lesional and peri-lesional skin of psoriasis patients, compared with the healthy control sample. CONCLUSION: Although various factors contribute to reduced skin hydration in the lesional and peri-lesional skin of psoriasis, AQP3 appears to be a key factor in the skin dehydration of psoriasis-affected skin. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2012-05 2012-04-26 /pmc/articles/PMC3346907/ /pubmed/22577267 http://dx.doi.org/10.5021/ad.2012.24.2.168 Text en Copyright © 2012 Korean Dermatological Association; The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Young Je, Young-Jin Lee, Sang-Sin Li, Zheng Jun Choi, Dae-Kyoung Kwon, Yoo-Bin Sohn, Kyung-Cheol Im, Myung Seo, Young Joon Lee, Jeung Hoon Changes in Transepidermal Water Loss and Skin Hydration according to Expression of Aquaporin-3 in Psoriasis |
title | Changes in Transepidermal Water Loss and Skin Hydration according to Expression of Aquaporin-3 in Psoriasis |
title_full | Changes in Transepidermal Water Loss and Skin Hydration according to Expression of Aquaporin-3 in Psoriasis |
title_fullStr | Changes in Transepidermal Water Loss and Skin Hydration according to Expression of Aquaporin-3 in Psoriasis |
title_full_unstemmed | Changes in Transepidermal Water Loss and Skin Hydration according to Expression of Aquaporin-3 in Psoriasis |
title_short | Changes in Transepidermal Water Loss and Skin Hydration according to Expression of Aquaporin-3 in Psoriasis |
title_sort | changes in transepidermal water loss and skin hydration according to expression of aquaporin-3 in psoriasis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346907/ https://www.ncbi.nlm.nih.gov/pubmed/22577267 http://dx.doi.org/10.5021/ad.2012.24.2.168 |
work_keys_str_mv | AT leeyoung changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis AT jeyoungjin changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis AT leesangsin changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis AT lizhengjun changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis AT choidaekyoung changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis AT kwonyoobin changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis AT sohnkyungcheol changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis AT immyung changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis AT seoyoungjoon changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis AT leejeunghoon changesintransepidermalwaterlossandskinhydrationaccordingtoexpressionofaquaporin3inpsoriasis |