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Prevention and Management of Gastroesophageal Varices in Cirrhosis

Variceal hemorrhage is one of the major complications of liver cirrhosis associated with significant mortality and morbidity. Its management has evolved over the past decade and has substantially reduced the rate of first and recurrent bleeding while decreasing mortality. In general, treatment of es...

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Detalles Bibliográficos
Autores principales: Chen, Yen-I, Ghali, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346976/
https://www.ncbi.nlm.nih.gov/pubmed/22577563
http://dx.doi.org/10.1155/2012/750150
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author Chen, Yen-I
Ghali, Peter
author_facet Chen, Yen-I
Ghali, Peter
author_sort Chen, Yen-I
collection PubMed
description Variceal hemorrhage is one of the major complications of liver cirrhosis associated with significant mortality and morbidity. Its management has evolved over the past decade and has substantially reduced the rate of first and recurrent bleeding while decreasing mortality. In general, treatment of esophageal varices can be divided into three categories: primary prophylaxis (prevention of first episode of bleeding), management of acute bleeding, and secondary prophylaxis (prevention of recurrent hemorrhage). The goal of this paper is to describe the current evidence behind the management of esophageal varices. We will discuss indications for primary prophylaxis and the different modes of therapy, pharmacological and interventional treatment in acute bleeding, and therapeutic options in preventing recurrent bleeding. The indications for TIPS will also be reviewed including its possible benefits in acute variceal hemorrhage.
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spelling pubmed-33469762012-05-10 Prevention and Management of Gastroesophageal Varices in Cirrhosis Chen, Yen-I Ghali, Peter Int J Hepatol Review Article Variceal hemorrhage is one of the major complications of liver cirrhosis associated with significant mortality and morbidity. Its management has evolved over the past decade and has substantially reduced the rate of first and recurrent bleeding while decreasing mortality. In general, treatment of esophageal varices can be divided into three categories: primary prophylaxis (prevention of first episode of bleeding), management of acute bleeding, and secondary prophylaxis (prevention of recurrent hemorrhage). The goal of this paper is to describe the current evidence behind the management of esophageal varices. We will discuss indications for primary prophylaxis and the different modes of therapy, pharmacological and interventional treatment in acute bleeding, and therapeutic options in preventing recurrent bleeding. The indications for TIPS will also be reviewed including its possible benefits in acute variceal hemorrhage. Hindawi Publishing Corporation 2012 2012-04-22 /pmc/articles/PMC3346976/ /pubmed/22577563 http://dx.doi.org/10.1155/2012/750150 Text en Copyright © 2012 Y.-I. Chen and P. Ghali. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Yen-I
Ghali, Peter
Prevention and Management of Gastroesophageal Varices in Cirrhosis
title Prevention and Management of Gastroesophageal Varices in Cirrhosis
title_full Prevention and Management of Gastroesophageal Varices in Cirrhosis
title_fullStr Prevention and Management of Gastroesophageal Varices in Cirrhosis
title_full_unstemmed Prevention and Management of Gastroesophageal Varices in Cirrhosis
title_short Prevention and Management of Gastroesophageal Varices in Cirrhosis
title_sort prevention and management of gastroesophageal varices in cirrhosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346976/
https://www.ncbi.nlm.nih.gov/pubmed/22577563
http://dx.doi.org/10.1155/2012/750150
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