Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.

Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectro...

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Detalles Bibliográficos
Autores principales: Xie, Zeping, Liu, Bing, Wang, Hongpeng, Yang, Shengxiang, Zhang, Hongyu, Wang, Yipeng, Ji, Naiyun, Qin, Song, Laatsch, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347014/
https://www.ncbi.nlm.nih.gov/pubmed/22611353
http://dx.doi.org/10.3390/md10030551
Descripción
Sumario:Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 µM. It appears to have potential as an anticancer agent with selective activity.

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