Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.

Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectro...

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Autores principales: Xie, Zeping, Liu, Bing, Wang, Hongpeng, Yang, Shengxiang, Zhang, Hongyu, Wang, Yipeng, Ji, Naiyun, Qin, Song, Laatsch, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347014/
https://www.ncbi.nlm.nih.gov/pubmed/22611353
http://dx.doi.org/10.3390/md10030551
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author Xie, Zeping
Liu, Bing
Wang, Hongpeng
Yang, Shengxiang
Zhang, Hongyu
Wang, Yipeng
Ji, Naiyun
Qin, Song
Laatsch, Hartmut
author_facet Xie, Zeping
Liu, Bing
Wang, Hongpeng
Yang, Shengxiang
Zhang, Hongyu
Wang, Yipeng
Ji, Naiyun
Qin, Song
Laatsch, Hartmut
author_sort Xie, Zeping
collection PubMed
description Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 µM. It appears to have potential as an anticancer agent with selective activity.
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spelling pubmed-33470142012-05-18 Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp. Xie, Zeping Liu, Bing Wang, Hongpeng Yang, Shengxiang Zhang, Hongyu Wang, Yipeng Ji, Naiyun Qin, Song Laatsch, Hartmut Mar Drugs Article Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 µM. It appears to have potential as an anticancer agent with selective activity. MDPI 2012-02-27 /pmc/articles/PMC3347014/ /pubmed/22611353 http://dx.doi.org/10.3390/md10030551 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xie, Zeping
Liu, Bing
Wang, Hongpeng
Yang, Shengxiang
Zhang, Hongyu
Wang, Yipeng
Ji, Naiyun
Qin, Song
Laatsch, Hartmut
Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.
title Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.
title_full Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.
title_fullStr Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.
title_full_unstemmed Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.
title_short Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.
title_sort kiamycin, a unique cytotoxic angucyclinone derivative from a marine streptomyces sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347014/
https://www.ncbi.nlm.nih.gov/pubmed/22611353
http://dx.doi.org/10.3390/md10030551
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