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Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule
Three new cembranoids, sarcocrassocolides M–O (1–3), have been isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1–3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347019/ https://www.ncbi.nlm.nih.gov/pubmed/22611358 http://dx.doi.org/10.3390/md10030617 |
| _version_ | 1782232264556412928 |
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| author | Lin, Wan-Yu Lu, Yi Chen, Bo-Wei Huang, Chiung-Yao Su, Jui-Hsin Wen, Zhi-Hong Dai, Chang-Feng Kuo, Yao-Haur Sheu, Jyh-Horng |
| author_facet | Lin, Wan-Yu Lu, Yi Chen, Bo-Wei Huang, Chiung-Yao Su, Jui-Hsin Wen, Zhi-Hong Dai, Chang-Feng Kuo, Yao-Haur Sheu, Jyh-Horng |
| author_sort | Lin, Wan-Yu |
| collection | PubMed |
| description | Three new cembranoids, sarcocrassocolides M–O (1–3), have been isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1–3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell lines and display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. |
| format | Online Article Text |
| id | pubmed-3347019 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33470192012-05-18 Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule Lin, Wan-Yu Lu, Yi Chen, Bo-Wei Huang, Chiung-Yao Su, Jui-Hsin Wen, Zhi-Hong Dai, Chang-Feng Kuo, Yao-Haur Sheu, Jyh-Horng Mar Drugs Article Three new cembranoids, sarcocrassocolides M–O (1–3), have been isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1–3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell lines and display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. MDPI 2012-03-08 /pmc/articles/PMC3347019/ /pubmed/22611358 http://dx.doi.org/10.3390/md10030617 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| spellingShingle | Article Lin, Wan-Yu Lu, Yi Chen, Bo-Wei Huang, Chiung-Yao Su, Jui-Hsin Wen, Zhi-Hong Dai, Chang-Feng Kuo, Yao-Haur Sheu, Jyh-Horng Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title | Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_full | Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_fullStr | Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_full_unstemmed | Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_short | Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule |
| title_sort | sarcocrassocolides m–o, bioactive cembranoids from the dongsha atoll soft coral sarcophyton crassocaule |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347019/ https://www.ncbi.nlm.nih.gov/pubmed/22611358 http://dx.doi.org/10.3390/md10030617 |
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