Immunological Function of Sphingosine 1-Phosphate in the Intestine

It has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activati...

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Detalles Bibliográficos
Autores principales: Kunisawa, Jun, Kiyono, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347024/
https://www.ncbi.nlm.nih.gov/pubmed/22666543
http://dx.doi.org/10.3390/nu4030154
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author Kunisawa, Jun
Kiyono, Hiroshi
author_facet Kunisawa, Jun
Kiyono, Hiroshi
author_sort Kunisawa, Jun
collection PubMed
description It has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism.
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spelling pubmed-33470242012-06-04 Immunological Function of Sphingosine 1-Phosphate in the Intestine Kunisawa, Jun Kiyono, Hiroshi Nutrients Review It has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism. MDPI 2012-03-06 /pmc/articles/PMC3347024/ /pubmed/22666543 http://dx.doi.org/10.3390/nu4030154 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kunisawa, Jun
Kiyono, Hiroshi
Immunological Function of Sphingosine 1-Phosphate in the Intestine
title Immunological Function of Sphingosine 1-Phosphate in the Intestine
title_full Immunological Function of Sphingosine 1-Phosphate in the Intestine
title_fullStr Immunological Function of Sphingosine 1-Phosphate in the Intestine
title_full_unstemmed Immunological Function of Sphingosine 1-Phosphate in the Intestine
title_short Immunological Function of Sphingosine 1-Phosphate in the Intestine
title_sort immunological function of sphingosine 1-phosphate in the intestine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347024/
https://www.ncbi.nlm.nih.gov/pubmed/22666543
http://dx.doi.org/10.3390/nu4030154
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AT kiyonohiroshi immunologicalfunctionofsphingosine1phosphateintheintestine

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