Influenza Virus Neuraminidase: Structure and Function

The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data...

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Detalles Bibliográficos
Autores principales: Shtyrya, Y.A., Mochalova, L.V., Bovin, N.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347517/
https://www.ncbi.nlm.nih.gov/pubmed/22649600
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author Shtyrya, Y.A.
Mochalova, L.V.
Bovin, N.V.
author_facet Shtyrya, Y.A.
Mochalova, L.V.
Bovin, N.V.
author_sort Shtyrya, Y.A.
collection PubMed
description The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals.
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spelling pubmed-33475172012-05-30 Influenza Virus Neuraminidase: Structure and Function Shtyrya, Y.A. Mochalova, L.V. Bovin, N.V. Acta Naturae Review The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals. A.I. Gordeyev 2009-07 /pmc/articles/PMC3347517/ /pubmed/22649600 Text en Copyright © 2009 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Shtyrya, Y.A.
Mochalova, L.V.
Bovin, N.V.
Influenza Virus Neuraminidase: Structure and Function
title Influenza Virus Neuraminidase: Structure and Function
title_full Influenza Virus Neuraminidase: Structure and Function
title_fullStr Influenza Virus Neuraminidase: Structure and Function
title_full_unstemmed Influenza Virus Neuraminidase: Structure and Function
title_short Influenza Virus Neuraminidase: Structure and Function
title_sort influenza virus neuraminidase: structure and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347517/
https://www.ncbi.nlm.nih.gov/pubmed/22649600
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