Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine

Induced pluripotent stem cells (iPSCs) are a new type of pluripotent cells that can be obtained by reprogramming animal and human differentiated cells. In this review, issues related to the nature of iPSCs are discussed and different methods of iPSC production are described. We particularly focused...

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Autores principales: Medvedev, S.P., Shevchenko, A.I., Zakian, S.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347549/
https://www.ncbi.nlm.nih.gov/pubmed/22649638
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author Medvedev, S.P.
Shevchenko, A.I.
Zakian, S.M.
author_facet Medvedev, S.P.
Shevchenko, A.I.
Zakian, S.M.
author_sort Medvedev, S.P.
collection PubMed
description Induced pluripotent stem cells (iPSCs) are a new type of pluripotent cells that can be obtained by reprogramming animal and human differentiated cells. In this review, issues related to the nature of iPSCs are discussed and different methods of iPSC production are described. We particularly focused on methods of iPSC production without the genetic modification of the cell genome and with means for increasing the iPSC production efficiency. The possibility and issues related to the safety of iPSC use in cell replacement therapy of human diseases and a study of new medicines are considered.
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spelling pubmed-33475492012-05-30 Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine Medvedev, S.P. Shevchenko, A.I. Zakian, S.M. Acta Naturae Research Article Induced pluripotent stem cells (iPSCs) are a new type of pluripotent cells that can be obtained by reprogramming animal and human differentiated cells. In this review, issues related to the nature of iPSCs are discussed and different methods of iPSC production are described. We particularly focused on methods of iPSC production without the genetic modification of the cell genome and with means for increasing the iPSC production efficiency. The possibility and issues related to the safety of iPSC use in cell replacement therapy of human diseases and a study of new medicines are considered. A.I. Gordeyev 2010-07 /pmc/articles/PMC3347549/ /pubmed/22649638 Text en Copyright © 2010 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Medvedev, S.P.
Shevchenko, A.I.
Zakian, S.M.
Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine
title Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine
title_full Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine
title_fullStr Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine
title_full_unstemmed Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine
title_short Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine
title_sort induced pluripotent stem cells: problems and advantages when applying them in regenerative medicine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347549/
https://www.ncbi.nlm.nih.gov/pubmed/22649638
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