Regulation of Store-Operated Channels by Scaffold Proteins in A431 Cells

Store-operated channels are major calcium influx pathways in nonexitable cells. Homer scaffold proteins are well known for their role in regulating calcium signaling. Here we report on a detailed single-channel level characterization of native store-operated channels regulated by Homer scaffold prot...

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Autores principales: Shalygin, A.V., Ryazantseva, M.A., Glushankova, L.N., Bezprozvanny, I.B., Mozhayeva, G.N., Kaznacheyeva, E. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347562/
https://www.ncbi.nlm.nih.gov/pubmed/22649656
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author Shalygin, A.V.
Ryazantseva, M.A.
Glushankova, L.N.
Bezprozvanny, I.B.
Mozhayeva, G.N.
Kaznacheyeva, E. V.
author_facet Shalygin, A.V.
Ryazantseva, M.A.
Glushankova, L.N.
Bezprozvanny, I.B.
Mozhayeva, G.N.
Kaznacheyeva, E. V.
author_sort Shalygin, A.V.
collection PubMed
description Store-operated channels are major calcium influx pathways in nonexitable cells. Homer scaffold proteins are well known for their role in regulating calcium signaling. Here we report on a detailed single-channel level characterization of native store-operated channels regulated by Homer scaffold proteins in A431 carcinoma cells. By applying the single-channel patch-clamp technique, we found that different types of store-operated calcium channels have different sensitivities to Homer proteins.
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spelling pubmed-33475622012-05-30 Regulation of Store-Operated Channels by Scaffold Proteins in A431 Cells Shalygin, A.V. Ryazantseva, M.A. Glushankova, L.N. Bezprozvanny, I.B. Mozhayeva, G.N. Kaznacheyeva, E. V. Acta Naturae Research Article Store-operated channels are major calcium influx pathways in nonexitable cells. Homer scaffold proteins are well known for their role in regulating calcium signaling. Here we report on a detailed single-channel level characterization of native store-operated channels regulated by Homer scaffold proteins in A431 carcinoma cells. By applying the single-channel patch-clamp technique, we found that different types of store-operated calcium channels have different sensitivities to Homer proteins. A.I. Gordeyev 2010 /pmc/articles/PMC3347562/ /pubmed/22649656 Text en Copyright © 2010 Park-media Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shalygin, A.V.
Ryazantseva, M.A.
Glushankova, L.N.
Bezprozvanny, I.B.
Mozhayeva, G.N.
Kaznacheyeva, E. V.
Regulation of Store-Operated Channels by Scaffold Proteins in A431 Cells
title Regulation of Store-Operated Channels by Scaffold Proteins in A431 Cells
title_full Regulation of Store-Operated Channels by Scaffold Proteins in A431 Cells
title_fullStr Regulation of Store-Operated Channels by Scaffold Proteins in A431 Cells
title_full_unstemmed Regulation of Store-Operated Channels by Scaffold Proteins in A431 Cells
title_short Regulation of Store-Operated Channels by Scaffold Proteins in A431 Cells
title_sort regulation of store-operated channels by scaffold proteins in a431 cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347562/
https://www.ncbi.nlm.nih.gov/pubmed/22649656
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