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Protein Engineering of Penicillin Acylase
Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam antibiotics and chiral compounds. In this review, the latest achievements in the production of recombinant enzymes are discussed, as well as the results of PA type G protein engineering.
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
A.I. Gordeyev
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347563/ https://www.ncbi.nlm.nih.gov/pubmed/22649651 |
| _version_ | 1782232293549539328 |
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| author | Tishkov, V.I. Savin, S.S. Yasnaya, A.S. |
| author_facet | Tishkov, V.I. Savin, S.S. Yasnaya, A.S. |
| author_sort | Tishkov, V.I. |
| collection | PubMed |
| description | Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam antibiotics and chiral compounds. In this review, the latest achievements in the production of recombinant enzymes are discussed, as well as the results of PA type G protein engineering. |
| format | Online Article Text |
| id | pubmed-3347563 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | A.I. Gordeyev |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33475632012-05-30 Protein Engineering of Penicillin Acylase Tishkov, V.I. Savin, S.S. Yasnaya, A.S. Acta Naturae Review Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam antibiotics and chiral compounds. In this review, the latest achievements in the production of recombinant enzymes are discussed, as well as the results of PA type G protein engineering. A.I. Gordeyev 2010 /pmc/articles/PMC3347563/ /pubmed/22649651 Text en Copyright © 2010 Park-media Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Tishkov, V.I. Savin, S.S. Yasnaya, A.S. Protein Engineering of Penicillin Acylase |
| title | Protein Engineering of Penicillin Acylase |
| title_full | Protein Engineering of Penicillin Acylase |
| title_fullStr | Protein Engineering of Penicillin Acylase |
| title_full_unstemmed | Protein Engineering of Penicillin Acylase |
| title_short | Protein Engineering of Penicillin Acylase |
| title_sort | protein engineering of penicillin acylase |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347563/ https://www.ncbi.nlm.nih.gov/pubmed/22649651 |
| work_keys_str_mv | AT tishkovvi proteinengineeringofpenicillinacylase AT savinss proteinengineeringofpenicillinacylase AT yasnayaas proteinengineeringofpenicillinacylase |