Reconstruction of Purine Metabolism in Bacillus subtilis to Obtain the Strain Producer of AICAR: A New Drug with a Wide Range of Therapeutic Applications

AICAR is a natural compound, an analogue and precursor of adenosine. As activator of AMP-activated protein kinase (AMPK), AICAR has a broad therapeutic potential, since it normalizes the carbohydrate and lipid metabolism and inhibits the proliferation of tumor cells. The synthesis of AICAR inBacillu...

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Detalles Bibliográficos
Autores principales: Lobanov, K.V., Errais Lopes, L., Korol’kova, N.V., Tyaglov, B.V., Glazunov, A.V., Shakulov, R.S., Mironov, A.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347571/
https://www.ncbi.nlm.nih.gov/pubmed/22649686

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