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Association Study of Xenobiotic Detoxication and Repair Genes with Malignant Brain Tumors in Children

This study presents the results of research on DNA polymorphism in children with malignant brain tumors (172 patients, 183 in the control group). Genotyping was performed using an allele-specific tetraprimer reaction for the genes of the first (CYP1A1 (2 sites)) and second phases of xenobiotic detox...

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Autores principales: Salnikova, L.E., Zelinskaya, N.I., Belopolskaya, O.B., Aslanyan, M.M., Rubanovich, A.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347583/
https://www.ncbi.nlm.nih.gov/pubmed/22649665
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author Salnikova, L.E.
Zelinskaya, N.I.
Belopolskaya, O.B.
Aslanyan, M.M.
Rubanovich, A.V.
author_facet Salnikova, L.E.
Zelinskaya, N.I.
Belopolskaya, O.B.
Aslanyan, M.M.
Rubanovich, A.V.
author_sort Salnikova, L.E.
collection PubMed
description This study presents the results of research on DNA polymorphism in children with malignant brain tumors (172 patients, 183 in the control group). Genotyping was performed using an allele-specific tetraprimer reaction for the genes of the first (CYP1A1 (2 sites)) and second phases of xenobiotic detoxication (GSTM1, GSTT1, GSTP1, GSTM3), DNA repair genesXRCC1, XPD(2 sites),OGG1, as well asNOS1andMTHFR.The increased risk of disease is associated with a minor variant ofCYP1A1(606G) (p = 0.009; OR = 1.50) and a deletion variant ofGSTT1, (p = 0.013, OR = 1.96). Maximum disease risk was observed in carriers of double deletions inGSTT1-GSTM1(p = 0.017, OR = 2.42). The obtained results are discussed in reference to literary data on the risk of malignant brain tumor formation in children and adults.
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spelling pubmed-33475832012-05-30 Association Study of Xenobiotic Detoxication and Repair Genes with Malignant Brain Tumors in Children Salnikova, L.E. Zelinskaya, N.I. Belopolskaya, O.B. Aslanyan, M.M. Rubanovich, A.V. Acta Naturae Research Article This study presents the results of research on DNA polymorphism in children with malignant brain tumors (172 patients, 183 in the control group). Genotyping was performed using an allele-specific tetraprimer reaction for the genes of the first (CYP1A1 (2 sites)) and second phases of xenobiotic detoxication (GSTM1, GSTT1, GSTP1, GSTM3), DNA repair genesXRCC1, XPD(2 sites),OGG1, as well asNOS1andMTHFR.The increased risk of disease is associated with a minor variant ofCYP1A1(606G) (p = 0.009; OR = 1.50) and a deletion variant ofGSTT1, (p = 0.013, OR = 1.96). Maximum disease risk was observed in carriers of double deletions inGSTT1-GSTM1(p = 0.017, OR = 2.42). The obtained results are discussed in reference to literary data on the risk of malignant brain tumor formation in children and adults. A.I. Gordeyev 2010 /pmc/articles/PMC3347583/ /pubmed/22649665 Text en Copyright © 2010 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Salnikova, L.E.
Zelinskaya, N.I.
Belopolskaya, O.B.
Aslanyan, M.M.
Rubanovich, A.V.
Association Study of Xenobiotic Detoxication and Repair Genes with Malignant Brain Tumors in Children
title Association Study of Xenobiotic Detoxication and Repair Genes with Malignant Brain Tumors in Children
title_full Association Study of Xenobiotic Detoxication and Repair Genes with Malignant Brain Tumors in Children
title_fullStr Association Study of Xenobiotic Detoxication and Repair Genes with Malignant Brain Tumors in Children
title_full_unstemmed Association Study of Xenobiotic Detoxication and Repair Genes with Malignant Brain Tumors in Children
title_short Association Study of Xenobiotic Detoxication and Repair Genes with Malignant Brain Tumors in Children
title_sort association study of xenobiotic detoxication and repair genes with malignant brain tumors in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347583/
https://www.ncbi.nlm.nih.gov/pubmed/22649665
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