The Role of p66shc in Oxidative Stress and Apoptosis

p66shcis a gene that regulates the level of reactive oxygen species (ROS), apoptosis induction, and lifespan in mammals. Miceknocked out forp66shchave a lifespan~30% longeranddemonstrate an enhanced resistance to oxidative stress and age-related pathologies such as hypercholesterolemia, ischemia, an...

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Detalles Bibliográficos
Autor principal: Galimov, E.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347587/
https://www.ncbi.nlm.nih.gov/pubmed/22649663
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author Galimov, E.R.
author_facet Galimov, E.R.
author_sort Galimov, E.R.
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description p66shcis a gene that regulates the level of reactive oxygen species (ROS), apoptosis induction, and lifespan in mammals. Miceknocked out forp66shchave a lifespan~30% longeranddemonstrate an enhanced resistance to oxidative stress and age-related pathologies such as hypercholesterolemia, ischemia, and hyperglycemia. In this respect, p66shc is a promising pharmacological target for the treatment of age-related diseases. In this review, an attempt has been made to survey and put to a critical analysis data concerning the involvement of p66shс in the different signaling pathways that regulate oxidative stress and apoptosis.
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spelling pubmed-33475872012-05-30 The Role of p66shc in Oxidative Stress and Apoptosis Galimov, E.R. Acta Naturae Review p66shcis a gene that regulates the level of reactive oxygen species (ROS), apoptosis induction, and lifespan in mammals. Miceknocked out forp66shchave a lifespan~30% longeranddemonstrate an enhanced resistance to oxidative stress and age-related pathologies such as hypercholesterolemia, ischemia, and hyperglycemia. In this respect, p66shc is a promising pharmacological target for the treatment of age-related diseases. In this review, an attempt has been made to survey and put to a critical analysis data concerning the involvement of p66shс in the different signaling pathways that regulate oxidative stress and apoptosis. A.I. Gordeyev 2010 /pmc/articles/PMC3347587/ /pubmed/22649663 Text en Copyright © 2010 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Galimov, E.R.
The Role of p66shc in Oxidative Stress and Apoptosis
title The Role of p66shc in Oxidative Stress and Apoptosis
title_full The Role of p66shc in Oxidative Stress and Apoptosis
title_fullStr The Role of p66shc in Oxidative Stress and Apoptosis
title_full_unstemmed The Role of p66shc in Oxidative Stress and Apoptosis
title_short The Role of p66shc in Oxidative Stress and Apoptosis
title_sort role of p66shc in oxidative stress and apoptosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347587/
https://www.ncbi.nlm.nih.gov/pubmed/22649663
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