Association of Cytokine Gene Alleles with the Inflammation of Human Periodontal Tissue

Gingivitis and periodontitis are chronic inflammatory diseases of the periodontal tissue in humans caused by both environmental and genetic factors. The human cytokine genes that regulate the immune response may play an important role in the development of these chronic inflammatory diseases. The ai...

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Autores principales: Safonova, A.V., Petrin, A.N., Arutyunov, S.D., Tsarev, V.N., Akulenko, L.A., Zorina, A.O., Rebrikov, D.V., Rubanovich, A.V., Borinskaya, S.A., Yankovsky, N.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347598/
https://www.ncbi.nlm.nih.gov/pubmed/22649680
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author Safonova, A.V.
Petrin, A.N.
Arutyunov, S.D.
Tsarev, V.N.
Akulenko, L.A.
Zorina, A.O.
Rebrikov, D.V.
Rubanovich, A.V.
Borinskaya, S.A.
Yankovsky, N.K.
author_facet Safonova, A.V.
Petrin, A.N.
Arutyunov, S.D.
Tsarev, V.N.
Akulenko, L.A.
Zorina, A.O.
Rebrikov, D.V.
Rubanovich, A.V.
Borinskaya, S.A.
Yankovsky, N.K.
author_sort Safonova, A.V.
collection PubMed
description Gingivitis and periodontitis are chronic inflammatory diseases of the periodontal tissue in humans caused by both environmental and genetic factors. The human cytokine genes that regulate the immune response may play an important role in the development of these chronic inflammatory diseases. The aim of this study is to analyze the allele status of eight human cytokine genes and to associate it with the inflammation of periodontal tissue in humans. A total of 296 unrelated males of Russian origin were studied. A significant association of theIL1BandIL6 minor alleles and gingivitis was found. In addition, we found a significant association of the OHI-S index with theIL18gene alleles. The influence of genetic factors on gingivitis may contribute to the understanding of the mechanisms of interaction between genetic and environmental factors in periodontal conditions, and to the identification of risk groups for effective prevention and treatment.
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spelling pubmed-33475982012-05-30 Association of Cytokine Gene Alleles with the Inflammation of Human Periodontal Tissue Safonova, A.V. Petrin, A.N. Arutyunov, S.D. Tsarev, V.N. Akulenko, L.A. Zorina, A.O. Rebrikov, D.V. Rubanovich, A.V. Borinskaya, S.A. Yankovsky, N.K. Acta Naturae Research Article Gingivitis and periodontitis are chronic inflammatory diseases of the periodontal tissue in humans caused by both environmental and genetic factors. The human cytokine genes that regulate the immune response may play an important role in the development of these chronic inflammatory diseases. The aim of this study is to analyze the allele status of eight human cytokine genes and to associate it with the inflammation of periodontal tissue in humans. A total of 296 unrelated males of Russian origin were studied. A significant association of theIL1BandIL6 minor alleles and gingivitis was found. In addition, we found a significant association of the OHI-S index with theIL18gene alleles. The influence of genetic factors on gingivitis may contribute to the understanding of the mechanisms of interaction between genetic and environmental factors in periodontal conditions, and to the identification of risk groups for effective prevention and treatment. A.I. Gordeyev 2011 /pmc/articles/PMC3347598/ /pubmed/22649680 Text en Copyright © 2011 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Safonova, A.V.
Petrin, A.N.
Arutyunov, S.D.
Tsarev, V.N.
Akulenko, L.A.
Zorina, A.O.
Rebrikov, D.V.
Rubanovich, A.V.
Borinskaya, S.A.
Yankovsky, N.K.
Association of Cytokine Gene Alleles with the Inflammation of Human Periodontal Tissue
title Association of Cytokine Gene Alleles with the Inflammation of Human Periodontal Tissue
title_full Association of Cytokine Gene Alleles with the Inflammation of Human Periodontal Tissue
title_fullStr Association of Cytokine Gene Alleles with the Inflammation of Human Periodontal Tissue
title_full_unstemmed Association of Cytokine Gene Alleles with the Inflammation of Human Periodontal Tissue
title_short Association of Cytokine Gene Alleles with the Inflammation of Human Periodontal Tissue
title_sort association of cytokine gene alleles with the inflammation of human periodontal tissue
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347598/
https://www.ncbi.nlm.nih.gov/pubmed/22649680
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