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Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006–2010

This is a continuation of our efforts to maintain a record of the evolution of HIV-1 infection in Puerto Rico by monitoring the expression levels of antiretroviral drug-resistance-associated mutations. Samples from 2,500 patients from 2006–2010 were analyzed using the TruGene HIV-1 genotyping kit an...

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Autores principales: Sepúlveda-Torres, Lycely del C., De La Rosa, Alexandra, Cumba, Luz, Boukli, Nawal, Ríos-Olivares, Eddy, Cubano, Luis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347695/
https://www.ncbi.nlm.nih.gov/pubmed/22593823
http://dx.doi.org/10.1155/2012/934041
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author Sepúlveda-Torres, Lycely del C.
De La Rosa, Alexandra
Cumba, Luz
Boukli, Nawal
Ríos-Olivares, Eddy
Cubano, Luis A.
author_facet Sepúlveda-Torres, Lycely del C.
De La Rosa, Alexandra
Cumba, Luz
Boukli, Nawal
Ríos-Olivares, Eddy
Cubano, Luis A.
author_sort Sepúlveda-Torres, Lycely del C.
collection PubMed
description This is a continuation of our efforts to maintain a record of the evolution of HIV-1 infection in Puerto Rico by monitoring the expression levels of antiretroviral drug-resistance-associated mutations. Samples from 2,500 patients from 2006–2010 were analyzed using the TruGene HIV-1 genotyping kit and the OpenGene DNA sequencing system. Results show that 58.8% of males and 65.3% of females had HIV-1 with resistance to at least one medication. The average number of HIV mutations was 6.0 in males and 6.1 in females. Statistically significant differences between men and women were recorded in the levels of HIV-1 expressed mutations and antiretroviral drug resistance. The most prevalent antiretroviral medication resistance shifted from zalcitabine to nevirapine and efavirenz in the five-year period. M184V and L63P were the dominant mutations for the reverse transcriptase and the protease genes, respectively, but an increase in the incidence of minority mutations was observed.
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spelling pubmed-33476952012-05-16 Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006–2010 Sepúlveda-Torres, Lycely del C. De La Rosa, Alexandra Cumba, Luz Boukli, Nawal Ríos-Olivares, Eddy Cubano, Luis A. AIDS Res Treat Research Article This is a continuation of our efforts to maintain a record of the evolution of HIV-1 infection in Puerto Rico by monitoring the expression levels of antiretroviral drug-resistance-associated mutations. Samples from 2,500 patients from 2006–2010 were analyzed using the TruGene HIV-1 genotyping kit and the OpenGene DNA sequencing system. Results show that 58.8% of males and 65.3% of females had HIV-1 with resistance to at least one medication. The average number of HIV mutations was 6.0 in males and 6.1 in females. Statistically significant differences between men and women were recorded in the levels of HIV-1 expressed mutations and antiretroviral drug resistance. The most prevalent antiretroviral medication resistance shifted from zalcitabine to nevirapine and efavirenz in the five-year period. M184V and L63P were the dominant mutations for the reverse transcriptase and the protease genes, respectively, but an increase in the incidence of minority mutations was observed. Hindawi Publishing Corporation 2012 2012-04-24 /pmc/articles/PMC3347695/ /pubmed/22593823 http://dx.doi.org/10.1155/2012/934041 Text en Copyright © 2012 Lycely del C. Sepúlveda-Torres et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sepúlveda-Torres, Lycely del C.
De La Rosa, Alexandra
Cumba, Luz
Boukli, Nawal
Ríos-Olivares, Eddy
Cubano, Luis A.
Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006–2010
title Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006–2010
title_full Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006–2010
title_fullStr Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006–2010
title_full_unstemmed Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006–2010
title_short Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006–2010
title_sort prevalence of drug resistance and associated mutations in a population of hiv-1(+) puerto ricans: 2006–2010
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347695/
https://www.ncbi.nlm.nih.gov/pubmed/22593823
http://dx.doi.org/10.1155/2012/934041
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