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Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals
Neutrophils represent the front-line defence cells in protecting organisms against infection and play an irreplaceable role in the proper performance of the immune system. As early as within the first minutes of stimulation, neutrophilic NADPH oxidase is activated, and cells release large quantities...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347721/ https://www.ncbi.nlm.nih.gov/pubmed/22577489 http://dx.doi.org/10.1155/2012/181295 |
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author | Ciz, Milan Denev, Petko Kratchanova, Maria Vasicek, Ondrej Ambrozova, Gabriela Lojek, Antonin |
author_facet | Ciz, Milan Denev, Petko Kratchanova, Maria Vasicek, Ondrej Ambrozova, Gabriela Lojek, Antonin |
author_sort | Ciz, Milan |
collection | PubMed |
description | Neutrophils represent the front-line defence cells in protecting organisms against infection and play an irreplaceable role in the proper performance of the immune system. As early as within the first minutes of stimulation, neutrophilic NADPH oxidase is activated, and cells release large quantities of highly toxic reactive oxygen species (ROS). These oxidants can be highly toxic not only for infectious agents but also for neighboring host tissues. Since flavonoids exhibit antioxidant and anti-inflammatory effects, they are subjects of interest for pharmacological modulation of ROS production. The present paper summarizes contemporary knowledge on the effects of various flavonoids on the respiratory burst of mammalian neutrophils. It can be summarized that the inhibitory effects of flavonoids on the respiratory burst of phagocytes are mediated via inhibition of enzymes involved in cell signaling as well as via modulation of redox status. However, the effects of flavonoids are even more complex, and several sites of action, depending upon the flavonoid structure and way of application, are included. |
format | Online Article Text |
id | pubmed-3347721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33477212012-05-10 Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals Ciz, Milan Denev, Petko Kratchanova, Maria Vasicek, Ondrej Ambrozova, Gabriela Lojek, Antonin Oxid Med Cell Longev Review Article Neutrophils represent the front-line defence cells in protecting organisms against infection and play an irreplaceable role in the proper performance of the immune system. As early as within the first minutes of stimulation, neutrophilic NADPH oxidase is activated, and cells release large quantities of highly toxic reactive oxygen species (ROS). These oxidants can be highly toxic not only for infectious agents but also for neighboring host tissues. Since flavonoids exhibit antioxidant and anti-inflammatory effects, they are subjects of interest for pharmacological modulation of ROS production. The present paper summarizes contemporary knowledge on the effects of various flavonoids on the respiratory burst of mammalian neutrophils. It can be summarized that the inhibitory effects of flavonoids on the respiratory burst of phagocytes are mediated via inhibition of enzymes involved in cell signaling as well as via modulation of redox status. However, the effects of flavonoids are even more complex, and several sites of action, depending upon the flavonoid structure and way of application, are included. Hindawi Publishing Corporation 2012 2012-04-23 /pmc/articles/PMC3347721/ /pubmed/22577489 http://dx.doi.org/10.1155/2012/181295 Text en Copyright © 2012 Milan Ciz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ciz, Milan Denev, Petko Kratchanova, Maria Vasicek, Ondrej Ambrozova, Gabriela Lojek, Antonin Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals |
title | Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals |
title_full | Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals |
title_fullStr | Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals |
title_full_unstemmed | Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals |
title_short | Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals |
title_sort | flavonoids inhibit the respiratory burst of neutrophils in mammals |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347721/ https://www.ncbi.nlm.nih.gov/pubmed/22577489 http://dx.doi.org/10.1155/2012/181295 |
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